Ubiquitin E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate (Raymond et al. 2009). E3 ligases includes a large, diverse set of proteins characterized by several defining motifs which include a HECT (homologous to E6-associated C-terminus), RING (Really Interesting New Gene) and U-box domains. The E3 ligases can be multisubunit complexes rather than a single polypeptide. Presently three different kinds of E3 complexes have been described called SCF, APC, and VHL. E3 ligases binds to both substrate and an E2 thioesterified with ubiquitin (E2-Ub).
Goto, E, Hotta, H, Ishido, S, Mito, M, Uematsu, M, Aoki, M, Ohmura-Hoshino, M, Matsuki, Y
Hatakeyama, S, Nakayama, KI
Deshaies, RJ, Joazeiro, CA
Ebstein, F, Kloetzel, PM, Urban, S, Seifert, U, Lange, N, Krüger, E
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