Interaction of beta-2-microglobulin (B2M) chain with class I HC

Stable Identifier
Reaction [transition]
Homo sapiens
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Interaction of calnexin (CNX) with MHC class I HC stabilizes it and facilitates the association of the beta2 microglobulin component (B2M). The two chains are linked noncovalently via interaction of B2M and the alpha3 domain of MHC HC. After formation of the HC:B2M heterodimer, the MHC complex dissociates from CNX.

Literature References
PubMed ID Title Journal Year
2450918 Specific associations of fluorescent beta-2-microglobulin with cell surfaces. The affinity of different H-2 and HLA antigens for beta-2-microglobulin

Edidin, M, Hochman, JH, DeMars, R, Shimizu, Y

J Immunol 1988
10064069 Cell surface expression of HLA-E: interaction with human beta2-microglobulin and allelic differences

Peterson, PA, Couturier, A, Weiss, EH, Pla, M, Ulbrecht, M, Srivastava, R, Martinozzi, S

Eur J Immunol 1999
14681859 Beta-2 microglobulin in ESRD: an in-depth review

Salsberg, JA, Winchester, JF, Levin, NW

Adv Ren Replace Ther 2003
Orthologous Events
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