Interaction of calnexin (CNX) with MHC class I HC stabilizes it and facilitates the association of the beta2 microglobulin component (B2M). The two chains are linked noncovalently via interaction of B2M and the alpha3 domain of MHC HC. After formation of the HC:B2M heterodimer, the MHC complex dissociates from CNX.
Edidin, M, Hochman, JH, DeMars, R, Shimizu, Y
Peterson, PA, Couturier, A, Weiss, EH, Pla, M, Ulbrecht, M, Srivastava, R, Martinozzi, S
Salsberg, JA, Winchester, JF, Levin, NW
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