Reactome | Interaction of beta-2-microglobulin (B2M) chain with class I HC

Interaction of beta-2-microglobulin (B2M) chain with class I HC

Stable Identifier

R-HSA-983146

Type

Reaction [transition]

Species

Homo sapiens

Compartment

integral component of lumenal side of endoplasmic reticulum membrane, endoplasmic reticulum lumen

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Interaction of beta-2-microglobulin (B2M) chain with class I HC

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Interaction of calnexin (CNX) with MHC class I HC stabilizes it and facilitates the association of the beta2 microglobulin component (B2M). The two chains are linked noncovalently via interaction of B2M and the alpha3 domain of MHC HC. After formation of the HC:B2M heterodimer, the MHC complex dissociates from CNX.

Literature References

PubMed ID	Title	Journal	Year
2450918	Specific associations of fluorescent beta-2-microglobulin with cell surfaces. The affinity of different H-2 and HLA antigens for beta-2-microglobulin Edidin, M, Hochman, JH, DeMars, R, Shimizu, Y	J Immunol	1988
10064069	Cell surface expression of HLA-E: interaction with human beta2-microglobulin and allelic differences Peterson, PA, Couturier, A, Weiss, EH, Pla, M, Ulbrecht, M, Srivastava, R, Martinozzi, S	Eur J Immunol	1999
14681859	Beta-2 microglobulin in ESRD: an in-depth review Salsberg, JA, Winchester, JF, Levin, NW	Adv Ren Replace Ther	2003