Interaction of beta-2-microglobulin (B2M) chain with class I HC

Stable Identifier
R-HSA-983146
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Interaction of calnexin (CNX) with MHC class I HC stabilizes it and facilitates the association of the beta2 microglobulin component (B2M). The two chains are linked noncovalently via interaction of B2M and the alpha3 domain of MHC HC. After formation of the HC:B2M heterodimer, the MHC complex dissociates from CNX.

Literature References
PubMed ID Title Journal Year
10064069 Cell surface expression of HLA-E: interaction with human beta2-microglobulin and allelic differences

Ulbrecht, M, Couturier, A, Martinozzi, S, Pla, M, Srivastava, R, Peterson, PA, Weiss, EH

Eur J Immunol 1999
2450918 Specific associations of fluorescent beta-2-microglobulin with cell surfaces. The affinity of different H-2 and HLA antigens for beta-2-microglobulin

Hochman, JH, Shimizu, Y, DeMars, R, Edidin, M

J Immunol 1988
14681859 Beta-2 microglobulin in ESRD: an in-depth review

Winchester, JF, Salsberg, JA, Levin, NW

Adv Ren Replace Ther 2003
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