Reactome | Transport of MHC heterotrimer to ER exit site

Transport of MHC heterotrimer to ER exit site

Stable Identifier

R-HSA-983138

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

integral component of lumenal side of endoplasmic reticulum membrane, endoplasmic reticulum lumen

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Transport of MHC heterotrimer to ER exit site

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When the loaded peptide is of a sufficiently high-affinity the trimeric complex is transported to a special ER exit site by a putative cargo receptor, B cell receptor-associated protein (BAP31), where it translocates to the cell surface, possibly by transport in COPII-coated vesicles.

Literature References

PubMed ID	Title	Journal	Year
14718384	Quality control of MHC class I maturation Paulsson, KM, Wang, P	FASEB J	2004
19342655	Interaction of Bap31 and MHC class I molecules and their traffic out of the endoplasmic reticulum Abe, F, Van Prooyen, N, Ladasky, JJ, Edidin, M	J Immunol	2009
17056546	Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules Ladasky, JJ, Boyle, S, Seth, M, Li, H, Pentcheva, T, Abe, F, Steinberg, SJ, Edidin, M	J Immunol	2006
11163199	Selective export of MHC class I molecules from the ER after their dissociation from TAP Spiliotis, ET, Manley, H, Osorio, M, Zúñiga, MC, Edidin, M	Immunity	2000