Reactome | Transport of MHC heterotrimer to ER exit site

Transport of MHC heterotrimer to ER exit site

Stable Identifier

R-HSA-983138

Type

Reaction

Species

Homo sapiens

Compartment

integral component of lumenal side of endoplasmic reticulum membrane, endoplasmic reticulum lumen

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Transport of MHC heterotrimer to ER exit site

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

When the loaded peptide is of a sufficiently high-affinity the trimeric complex is transported to a special ER exit site by a putative cargo receptor, B cell receptor-associated protein (BAP31), where it translocates to the cell surface, possibly by transport in COPII-coated vesicles.

Literature References

PubMed ID	Title	Journal	Year
19342655	Interaction of Bap31 and MHC class I molecules and their traffic out of the endoplasmic reticulum Edidin, M, Van Prooyen, N, Ladasky, JJ, Abe, F	J Immunol	2009
14718384	Quality control of MHC class I maturation Paulsson, KM, Wang, P	FASEB J	2004
17056546	Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules Seth, M, Edidin, M, Li, H, Boyle, S, Pentcheva, T, Abe, F, Ladasky, JJ, Steinberg, SJ	J Immunol	2006
11163199	Selective export of MHC class I molecules from the ER after their dissociation from TAP Manley, H, Spiliotis, ET, Edidin, M, Zúñiga, MC, Osorio, M	Immunity	2000