Reactome | ERAP2 [endoplasmic reticulum lumen]

ERAP2 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-983097

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Endoplasmic reticulum aminopeptidase 2, ERAP2_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
      - Trimming of peptides in ER (Homo sapiens)
        
        ERAP1/2 [endoplasmic reticulum lumen] (Homo sapiens)
        
        ERAP2 [endoplasmic reticulum lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6P179 ERAP2

Gene Names

ERAP2, LRAP

Chain

chain:1-960

Reference Genes

BioGPS Gene:64167 ERAP2

COSMIC (genes):ERAP2 ERAP2

CTD Gene:64167 ERAP2

dbSNP Gene:64167 ERAP2

ENSEMBL:ENSG00000164308 ERAP2

HGNC:29499 ERAP2

KEGG Gene (Homo sapiens):64167 ERAP2

Monarch:64167 ERAP2

NCBI Gene:64167 ERAP2

OMIM:609497 ERAP2

UCSC:Q6P179 ERAP2

Reference Transcript

Other Identifiers

0001230731

11722573_a_at

11745601_a_at

11747137_x_at

1554272_PM_at

1554272_at

1554273_PM_a_at

1554273_a_at

16987531

219759_3p_at

219759_PM_at

219759_at

227462_PM_at

227462_at

235104_PM_at

235104_at

2821368

2821369

2821370

2821371

2821372

2821373

2821374

2821375

2821376

2821378

2821379

2821382

2821383

2821385

2821387

2821388

2821389

2821390

2821392

2821394

2821399

2821400

2821402

2821403

2821404

2821406

2821408

2821409

2821410

2821411

2821412

44792_s_at

60854_at

64167

8107044

81092_g_at

82982_at

88809_at

A_14_P100960

A_14_P121724

A_23_P30243

A_24_P342171

GE62893

GO:0002250

GO:0002376

GO:0002474

GO:0003013

GO:0003674

GO:0004175

GO:0004177

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0005789

GO:0005886

GO:0006508

GO:0007165

GO:0008150

GO:0008217

GO:0008233

GO:0008237

GO:0008270

GO:0009056

GO:0016020

GO:0016021

GO:0016787

GO:0019885

GO:0034641

GO:0042277

GO:0043167

GO:0043171

GO:0043226

GO:0046872

GO:0070006

HMNXSV003010535

Hs.124764.0.A1_3p_at

Hs.23054.0.A1_3p_at

Hs2.280380.3.S1_3p_at

Hs2.280380.3.S1_3p_x_at

ILMN_1743145

ILMN_2123312

PH_hs_0024235

TC05000471.hg

g11641260_3p_x_at

Participates

as a member of

ERAP1/2 [endoplasmic reticulum lumen] (Homo sapiens)

Inferred To

BEST:LD34564 [endoplasmic reticulum lumen] (Drosophila melanogaster)

AAP1 [endoplasmic reticulum lumen] (Saccharomyces cerevisiae)

TMA108 [endoplasmic reticulum lumen] (Saccharomyces cerevisiae)

APE2 [endoplasmic reticulum lumen] (Saccharomyces cerevisiae)

BcDNA:GH07466 [endoplasmic reticulum lumen] (Drosophila melanogaster)

psaA [endoplasmic reticulum lumen] (Dictyostelium discoideum)

Dmel\CG8773 [endoplasmic reticulum lumen] (Drosophila melanogaster)

Dmel\CG6071 [endoplasmic reticulum lumen] (Drosophila melanogaster)

ape1 [endoplasmic reticulum lumen] (Schizosaccharomyces pombe)

Dmel\CG31198 [endoplasmic reticulum lumen] (Drosophila melanogaster)

Psa [endoplasmic reticulum lumen] (Drosophila melanogaster)

Homologues of ERAP2 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

Homologues of ERAP2 [endoplasmic reticulum lumen] (Dictyostelium discoideum)

Homologues of ERAP2 [endoplasmic reticulum lumen] (Drosophila melanogaster)

Homologues of ERAP2 [endoplasmic reticulum lumen] (Saccharomyces cerevisiae)

Dmel\CG11951 [endoplasmic reticulum lumen] (Drosophila melanogaster)

psaB [endoplasmic reticulum lumen] (Dictyostelium discoideum)

BG:DS00365.1 [endoplasmic reticulum lumen] (Drosophila melanogaster)

erap2 [endoplasmic reticulum lumen] (Danio rerio)

CG11955 [endoplasmic reticulum lumen] (Drosophila melanogaster)

CG31177 [endoplasmic reticulum lumen] (Drosophila melanogaster)

anp-1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

Dmel\CG5849 [endoplasmic reticulum lumen] (Drosophila melanogaster)

CG5839 [endoplasmic reticulum lumen] (Drosophila melanogaster)

CG8775 [endoplasmic reticulum lumen] (Drosophila melanogaster)

ERAP2 [endoplasmic reticulum lumen] (Bos taurus)

ERAP2 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

ERAP2 [endoplasmic reticulum lumen] (Canis familiaris)

ERAP2 [endoplasmic reticulum lumen] (Dictyostelium discoideum)

ERAP2 [endoplasmic reticulum lumen] (Sus scrofa)

Dmel\CG8774 [endoplasmic reticulum lumen] (Drosophila melanogaster)

Dmel\CG9806 [endoplasmic reticulum lumen] (Drosophila melanogaster)

SP1029 [endoplasmic reticulum lumen] (Drosophila melanogaster)

pam-1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

pepCG2111 [endoplasmic reticulum lumen] (Drosophila melanogaster)

Cross References

RefSeq

NP_001123612.1, NP_001316158.1, NP_071745.1, NP_001316162.1

Guide to Pharmacology - Targets

1567

OpenTargets

ENSG00000164308

ZINC - FDA approved

ERAP2_HUMAN

ZINC - Substances

ERAP2_HUMAN

ZINC target

Q6P179

PRO

Q6P179

PDB

4JBS, 6EA4, 5AB2, 4E36, 5J6S, 5K1V, 5CU5, 3SE6, 5AB0

HPA

ENSG00000164308-ERAP2

GeneCards

Q6P179

Ensembl

ENST00000379904, ENSP00000400376, ENST00000437043, ENST00000513084, ENSP00000369235, ENST00000510309, ENSP00000425758, ENSG00000164308, ENSP00000421849

Pharos - Targets

Q6P179

ZINC - Predictions - Purchasable

ERAP2_HUMAN

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