EYA1, PAX2, and HOX11 paralog bind the GDNF gene

Stable Identifier
R-HSA-9830969
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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EYA1, PAX2, and HOX11 paralog bind the GDNF gene
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HOXA11 (or HOXC11 or HOXD11) , EYA1, and PAX2 physically interact to form a complex (inferred from mouse homologs) which binds the GDNF gene (inferred from mouse Hox11:Eya1:Pax2 binding the Six2 gene in Gong et al. 2007). The components of the HOX11:EYA1:PAX2 complex synergistically activate expression of GDNF (inferred from the mouse homologs).
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Inferred From
Eya1, Pax2, and Hox11 paralog bind the Gdnf gene (Mus musculus)
Authored
May, B  (2023-03-15)
Created
May, B  (2023-03-17)
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