GDNF from the metanephric mesenchyme binds RET:GFRA1 on the nephric duct

Stable Identifier
R-HSA-9830754
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
3/5
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GDNF from the metanephric mesenchyme binds RET:GFRA1 on the nephric duct
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Glial cell line-derived factor (GDNF) binds the RET recpeptor tyrosine kinase and the GFRA1 coreceptor, causing phosphorylation and activation of RET (inferred from mouse homologs, reviewed in Kawai and Takahashi et al. 2020). GDNF is secreted by the metanephric mesenchyme and interacts with RET on the nephric duct (inferred from mouse homologs). The interaction between GDNF and RET is required for formation of the ureteric bud by the nephric duct in response to contact with the metanephric mesenchyme (inferred from mouse embryos).
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Gdnf from metanephric mesenchyme binds Ret:Gfra1 in the nephric duct (Mus musculus)
Authored
May, B  (2023-03-13)
Created
May, B  (2023-03-14)
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