LHX1 binds the NPNT gene

Stable Identifier
R-HSA-9830668
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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LHX1 binds the NPNT gene
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LHX1 (also called LIM1) binds three conserved sites near the coding region of the Nephronectin (NPNT) gene. One site is about 14 kb upstream of the transcription start and two sites are in the 3' untranslated region (inferred from mouse homologs in Boualia et al. 2013). In mice, loss of Lhx1 results in complete loss of Npnt expression (Boualia et al. 2013). NPNT secreted from the nephric duct interacts with Integrin alpha8/beta1 (ITGA8) on metanephric mesenchyme cells to regulate expression of GDNF and formation of the ureteric bud (Brandenberger et al. 2001).
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Lhx1 binds the Npnt gene (Mus musculus)
Authored
May, B  (2023-03-12)
Created
May, B  (2023-03-13)
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