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Expression of NPNT in the nephric duct
Stable Identifier
R-HSA-9830475
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
,
extracellular region
ReviewStatus
3/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Kidney development (Homo sapiens)
Formation of the nephric duct (Homo sapiens)
Expression of NPNT in the nephric duct (Homo sapiens)
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Nephronectin (NPNT) is expressed in the ureteric bud epithelium and secreted into the extracellular space where it interacts with Intergrin alpha-8 (ITGA8) to regulate development of the ureteric bud (inferred from mouse homologs in Brandenberger et al. 2001, Boualia et al. 2013). LHX1 binds an upstream site and two sites in the 3' untranslated region of the NPNT gene to activate expression (inferred from mouse homologs in Boualia et al. 2013). In mouse embryos, loss of Lhx1 causes complete loss of Npnt expression. In mice, Pax2 and Pax8 also enhance expression of Npnt, however this effect may indirect through the activation of Lhx1 by Pax2 and Pax8 (Boualia et al. 2013).
Participants
Input
NPNT gene [nucleoplasm]
(Homo sapiens)
Output
NPNT [extracellular region]
(Homo sapiens)
Participates
as an event of
Formation of the nephric duct (Homo sapiens)
This event is regulated
Positively by
Regulator
LHX1:NPNT gene [nucleoplasm]
(Homo sapiens)
Active Unit
LHX1 [nucleoplasm]
Inferred From
Expression of Npnt in the nephric duct (Mus musculus)
Authored
May, B (2023-03-10)
Created
May, B (2023-03-12)
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