G mRNA is translated into nascent secreted G protein

Stable Identifier
R-HSA-9828717
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
ReviewStatus
5/5
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G mRNA is translated into nascent secreted G protein
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Human respiratory syncytial virus (hRSV) glycoprotein (G) mRNA contains two initiation codons (AUG) (Roberts et al. 1994). When translation is started from the second AUG (located at position 48 relative to the first initiation codon), the resulting soluble G protein variant sG of 251 amino acids possesses a partial transmembrane domain (Hendricks et al, 1987; Hendricks et al, 1988; Roberts et al. 1994; reviewed in Anderson et al. 2021).
Literature References
PubMed ID Title Journal Year
3585282 Appearance of a soluble form of the G protein of respiratory syncytial virus in fluids of infected cells

Patterson, JL, Hendricks, DA, Baradaran, K, McIntosh, K

J Gen Virol 1987
8207828 The membrane-associated and secreted forms of the respiratory syncytial virus attachment glycoprotein G are synthesized from alternative initiation codons

Lichtenstein, D, Roberts, SR, Wertz, GW, Ball, LA

J Virol 1994
3373568 Further characterization of the soluble form of the G glycoprotein of respiratory syncytial virus

Patterson, JL, Hendricks, DA, McIntosh, K

J Virol 1988
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Authored
Stephan, R  (2023-03-05)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Orlic-Milacic, M  (2023-02-16)
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