M2 mRNA is translated into protein M2-2

Stable Identifier
R-HSA-9828714
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human respiratory syncytial virus A
Compartment
cytosol
ReviewStatus
5/5
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M2 mRNA is translated into protein M2-2
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Human respiratory syncytial virus (hRSV) M2 gene contains two overlapping open reading frames. Ribosomes translate the second ORF to the M2-2 protein after departing from the first ORF. This coupled translation depends on a coding region in the mRNA containing a high degree of secondary structure, directing the ribosome back onto the start codon of the second ORF (Ahmadian et al, 2000; Gould & Easton, 2005; Gould & Easton, 2007)
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Authored
Stephan, R  (2023-03-28)
Reviewed
Bergeron, HC  (2023-11-03)
Created
Orlic-Milacic, M  (2023-02-16)
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