SOX17 binds the CXCR4 gene

Stable Identifier
R-HSA-9828034
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SOX17 binds the CXCR4 gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In human primordial germ cells (PGCs) differentiated from embryonic stem cells in vitro, SOX17 binds and activates the gene encoding CXCR4, the receptor for the chemokine CXCL12 (Tang et al. 2022). In mouse embryos (Ara et al. 2003, Molyneaux et al. 2003) and zebrafish embryos (Doitsidou et al. 2002), Cxcr4 on PGCs interacts with its ligand, Cxcl12 which is secreted by somatopleur mesenchyme and genital ridges, and guides the migration of PGCs.
Literature References
PubMed ID Title Journal Year
35411086 Sequential enhancer state remodelling defines human germline competence and specification

Castillo-Venzor, A, Tang, WWC, Surani, MA, Sun, D, Gruhn, WH, Penfold, CA, Kobayashi, T, Irie, N, Morgan, MD

Nat Cell Biol 2022
Participants
Input
Output
Participates
as an event of
Authored
May, B  (2023-02-09)
Reviewed
Tam, PPL  (2023-05-03)
Created
May, B  (2023-02-09)
Cite Us!