SOX17, TFAP2C, and PRDM1 (BLIMP1) bind the NANOS3 gene

Stable Identifier
R-HSA-9828027
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SOX17, TFAP2C, and PRDM1 (BLIMP1) bind the NANOS3 gene
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SOX17, TFAP2C, and PRDM1 (also called BLIMP1) are expressed during initial differentiation of human primordial germ cells in vitro, bind upstream of the transcription start site of the NANOS3 gene, and activate expression of NANOS3 (Tang et al. 2022). TFAP2C and PRDM1 also bind near the last exon of the NANOS3 gene (Tang et al. 2022). In mice, Nanos3 encodes an RNA-binding protein the function of which is required for migration of germ cells to the genital ridge (Tsuda et al. 2003).
Literature References
PubMed ID Title Journal Year
35411086 Sequential enhancer state remodelling defines human germline competence and specification

Castillo-Venzor, A, Tang, WWC, Surani, MA, Sun, D, Gruhn, WH, Penfold, CA, Kobayashi, T, Irie, N, Morgan, MD

Nat Cell Biol 2022
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Authored
May, B  (2023-02-09)
Reviewed
Tam, PPL  (2023-05-03)
Created
May, B  (2023-02-09)
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