Expression of POU5F1 (OCT4) in primordial germ cells

Stable Identifier
R-HSA-9828023
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of POU5F1 (OCT4) in primordial germ cells
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The pluripotency factor POU5F1 (OCT4) (Nichols et al. 1998) is expressed in human primordial germ cells differentiated in vitro (Irie et al. 2015, Sasaki et al. 2015, Chen et al. 2018, Fang et al. 2020, Tang et al. 2022). During differentiation of primordial germ cells, SOX17 and TFAP2C bind enhancers of the POU5F1 gene and activate its transcription (Tang et al. 2022, Chen et al. 2018). Absence of SOX17 leads to total loss of POU5F1 expression in embryoids (Irie et al. 2015). PRDM1 may (Irie et al. 2015) or may not (Sasaki et al. 2015) enhance expression of POU5F1. POU5F1 acts with PRDM1 and PAX5 to activate expression of germline genes and repress gene expression in somatic cell lineages (Fang et al. 2020).
Literature References
PubMed ID Title Journal Year
26189426 Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells

Sekiguchi, K, Moritoki, Y, Ohta, H, Kurimoto, K, Yamamoto, T, Nakagawa, M, Yamanaka, S, Mori, T, Saitou, M, Tsuchiya, H, Takahashi, K, Okamoto, I, Yamamoto, T, Woltjen, K, Sakuma, T, Yokobayashi, S, Sasaki, K, Iwatani, C, Nakamura, S, Yabuta, Y, Nakamura, T

Cell Stem Cell 2015
29713018 A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells

Wiedenheft, B, Surani, MA, Wang, Z, Fang, F, Orwig, KE, Irie, N, Angulo, B, Sukhwani, M, Mazurie, A, Xia, N, Carey, CC, Reijo Pera, RA, Cui, J, Wilkinson, R

Nat Cell Biol 2018
30590035 The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation

Clark, AT, Ho, J, Kim, R, Pastor, WA, Zimmerman, J, Gell, JJ, Hosohama, L, Liu, W, Jacobsen, SE, Chen, D, Aslanyan, M

Cell Rep 2018
25543152 SOX17 is a critical specifier of human primordial germ cell fate

Dietmann, S, Surani, MA, Viukov, S, Tang, WW, Hanna, JH, Weinberger, L, Manor, YS, Kobayashi, T, Irie, N

Cell 2015
32127035 Analysis of multi-lineage gene expression dynamics during primordial germ cell induction from human induced pluripotent stem cells

Zhao, Q, Fang, F, Ni, K, Xiong, C, Li, Z

Stem Cell Res Ther 2020
35411086 Sequential enhancer state remodelling defines human germline competence and specification

Castillo-Venzor, A, Tang, WWC, Surani, MA, Sun, D, Gruhn, WH, Penfold, CA, Kobayashi, T, Irie, N, Morgan, MD

Nat Cell Biol 2022
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
SOX17:TFAP2C:POU5F1 gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2023-02-09)
Reviewed
Tam, PPL  (2023-05-03)
Created
May, B  (2023-02-09)
Cite Us!