SOX17 binds the TET2 gene

Stable Identifier
R-HSA-9827999
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SOX17 binds the TET2 gene and activates its expression during differentiation of human primordial germ cells from embryonic stem cells in vitro (Tang et al. 2022). TET2 encodes a methylcytosine dioxygenese that converts 5-methylcytidine in DNA to 5-hydroxymethylcytidine (inferred from the mouse homolog in Ito et al. 2010).
Literature References
PubMed ID Title Journal Year
35411086 Sequential enhancer state remodelling defines human germline competence and specification

Castillo-Venzor, A, Tang, WWC, Surani, MA, Sun, D, Gruhn, WH, Penfold, CA, Kobayashi, T, Irie, N, Morgan, MD

Nat Cell Biol 2022
Participants
Participates
Authored
Reviewed
Created
Cite Us!