Expression of NANOG in primordial germ cells

Stable Identifier
R-HSA-9827997
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of NANOG in primordial germ cells
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The pluripotency-related factor NANOG (Mitsui et al. 2003) is expressed in human primordial germ cells differentiated in vitro (Irie et al. 2015, Tang et al. 2022). SOX17 and TFAP2C bind enhancers upstream of the NANOG transcription start site and activate NANOG expression (Irie et al. 2015, Tang et al. 2022). PRDM1 may (Irie et al. 2015) or may not (Sasaki et al. 2015) enhance expression of NANOG.
Literature References
PubMed ID Title Journal Year
26189426 Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells

Sekiguchi, K, Moritoki, Y, Ohta, H, Kurimoto, K, Yamamoto, T, Nakagawa, M, Yamanaka, S, Mori, T, Saitou, M, Tsuchiya, H, Takahashi, K, Okamoto, I, Yamamoto, T, Woltjen, K, Sakuma, T, Yokobayashi, S, Sasaki, K, Iwatani, C, Nakamura, S, Yabuta, Y, Nakamura, T

Cell Stem Cell 2015
25543152 SOX17 is a critical specifier of human primordial germ cell fate

Dietmann, S, Surani, MA, Viukov, S, Tang, WW, Hanna, JH, Weinberger, L, Manor, YS, Kobayashi, T, Irie, N

Cell 2015
35411086 Sequential enhancer state remodelling defines human germline competence and specification

Castillo-Venzor, A, Tang, WWC, Surani, MA, Sun, D, Gruhn, WH, Penfold, CA, Kobayashi, T, Irie, N, Morgan, MD

Nat Cell Biol 2022
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
SOX17:TFAP2C:NANOG gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2023-02-09)
Reviewed
Tam, PPL  (2023-05-03)
Created
May, B  (2023-02-09)
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