Expression of NANOS3 in primordial germ cells

Stable Identifier
R-HSA-9827995
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of NANOS3 in primordial germ cells
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NANOS3, an RNA binding protein, is expressed during differentiation of primordial germ cells (PGCs) in vitro (Irie et al. 2015, Fang et al. 2020, Tang et al. 2022). Expression of NANOS3 coincides with expression of NANOG, POU5F1 (OCT4), and TFAP2C (Irie et al. 2015). SOX17 (Irie et al. 2015, Kojima et al. 2021, Tang et al. 2022), TFAP2C (Kojima et al. 2021, Tang et al. 2022), and PRDM1 (Tang et al. 2022, Irie et al. 2022) directly activate expression of NANOS3 in PGCs differentiated in vitro. SOX17 is required to maintain expression of NANOS3 (Kojima et al. 2017). Reduced expression of NANOS3 in human embryonic stem cells is associated with fewer numbers of germ cells and reduced expression of germline genes during differentiation in vitro (Julaton et al. 2011). In mice, Nanos3 is required for migration of germ cells to the genital ridge (Tsuda et al. 2003).
Literature References
PubMed ID Title Journal Year
28985527 Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells

Saitou, M, Nakaki, F, Yamamoto, T, Woltjen, K, Yokobayashi, S, Hotta, A, Sasaki, K, Kojima, Y, Sakai, Y, Nagaoka, S, Yabuta, Y, Nakamura, T

Cell Stem Cell 2017
33608411 GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program

Saitou, M, Tsuchiya, H, Murase, Y, Okamoto, I, Yamashiro, C, Yamamoto, T, Nakaya, M, Iwatani, C, Kojima, Y, Tsukiyama, T, Yabuta, Y, Nakamura, T

Life Sci Alliance 2021
25543152 SOX17 is a critical specifier of human primordial germ cell fate

Dietmann, S, Surani, MA, Viukov, S, Tang, WW, Hanna, JH, Weinberger, L, Manor, YS, Kobayashi, T, Irie, N

Cell 2015
32127035 Analysis of multi-lineage gene expression dynamics during primordial germ cell induction from human induced pluripotent stem cells

Zhao, Q, Fang, F, Ni, K, Xiong, C, Li, Z

Stem Cell Res Ther 2020
35411086 Sequential enhancer state remodelling defines human germline competence and specification

Castillo-Venzor, A, Tang, WWC, Surani, MA, Sun, D, Gruhn, WH, Penfold, CA, Kobayashi, T, Irie, N, Morgan, MD

Nat Cell Biol 2022
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
SOX17:TFAP2C:PRDM1:NANOS3 gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2023-02-09)
Reviewed
Tam, PPL  (2023-05-03)
Created
May, B  (2023-02-09)
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