Expression of PDPN in primordial germ cells

Stable Identifier
R-HSA-9827993
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Podoplanin (PDPN) is expressed in human primordial germ cells (PGCs) differentiated from embryonic stem cells in vitro (Sasaki et al. 2015, Mishra et al. 2021, Tang et al. 2022). SOX17 directly activates expression of PDPN (Tang et al. 2022). PDPN protein is located on the plasma membrane and mediates cell migration and adhesion (reviewed in Dang et al. 2014). PDPN is expressed in the migratory primordial germ cells (Mishra et al. 2021).
Literature References
PubMed ID Title Journal Year
33470497 Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells

Mishra, S, Taelman, J, Popovic, M, Tilleman, L, Duthoo, E, Van Der Jeught, M, Deforce, D, van Nieuwerburgh, F, Menten, B, De Sutter, P, Boel, A, Chuva De Sousa Lopes, SM, Heindryckx, B

Stem Cells 2021
26189426 Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells

Sasaki, K, Yokobayashi, S, Nakamura, T, Okamoto, I, Yabuta, Y, Kurimoto, K, Ohta, H, Moritoki, Y, Iwatani, C, Tsuchiya, H, Nakamura, S, Sekiguchi, K, Sakuma, T, Yamamoto, T, Mori, T, Woltjen, K, Nakagawa, M, Yamamoto, T, Takahashi, K, Yamanaka, S, Saitou, M

Cell Stem Cell 2015
34065661 Sex-Specific Isolation and Propagation of Human Premeiotic Fetal Germ Cells and Germ Cell-Like Cells

Mishra, S, Taelman, J, Chang, YW, Boel, A, De Sutter, P, Heindryckx, B, Chuva De Sousa Lopes, SM

Cells 2021
35411086 Sequential enhancer state remodelling defines human germline competence and specification

Tang, WWC, Castillo-Venzor, A, Gruhn, WH, Kobayashi, T, Penfold, CA, Morgan, MD, Sun, D, Irie, N, Surani, MA

Nat Cell Biol 2022
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