Expression of TET2 in primordial germ cells

Stable Identifier
R-HSA-9827992
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of TET2 in primordial germ cells
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The methylcytosine dioxygenase TET2 is expressed during differentiation of primordial germ cells (PGCs) from embryonic stems cells in vitro (Irie et al. 2015, Tang et al. 2022). SOX17 activates expression of TET2 (Irie et al. 2015, Tang et al. 2022). TET2 encodes a methylcytosine dioxygenase which converts 5-methylcytidine in DNA into 5-hydroxymethylcytidine and regulates DNA methylation (inferred from the mouse homolog in Ito et al. 2010).
Literature References
PubMed ID Title Journal Year
25543152 SOX17 is a critical specifier of human primordial germ cell fate

Dietmann, S, Surani, MA, Viukov, S, Tang, WW, Hanna, JH, Weinberger, L, Manor, YS, Kobayashi, T, Irie, N

Cell 2015
35411086 Sequential enhancer state remodelling defines human germline competence and specification

Castillo-Venzor, A, Tang, WWC, Surani, MA, Sun, D, Gruhn, WH, Penfold, CA, Kobayashi, T, Irie, N, Morgan, MD

Nat Cell Biol 2022
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
SOX17:TET2 gene [nucleoplasm] (Homo sapiens)
Active Unit
SOX17 [nucleoplasm]
Authored
May, B  (2023-02-09)
Reviewed
Tam, PPL  (2023-05-03)
Created
May, B  (2023-02-09)
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