SOX17 and TFAP2C bind the PRDM1 gene

Stable Identifier
R-HSA-9827882
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SOX17 and TFAP2C bind the PRDM1 gene
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SOX17 and TFAP2C bind the promoter of the PR domain-containing zinc finger protein 1 gene (PRDM1, also called BLIMP1) and activate expression of PRDM1 in PGCs in vitro (Kojima et al. 2015, Tang et al. 2022). PRDM1 generally acts as a repressor of transcription.
Literature References
PubMed ID Title Journal Year
28985527 Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells

Saitou, M, Nakaki, F, Yamamoto, T, Woltjen, K, Yokobayashi, S, Hotta, A, Sasaki, K, Kojima, Y, Sakai, Y, Nagaoka, S, Yabuta, Y, Nakamura, T

Cell Stem Cell 2017
35411086 Sequential enhancer state remodelling defines human germline competence and specification

Castillo-Venzor, A, Tang, WWC, Surani, MA, Sun, D, Gruhn, WH, Penfold, CA, Kobayashi, T, Irie, N, Morgan, MD

Nat Cell Biol 2022
Participants
Input
Output
Participates
as an event of
Authored
May, B  (2023-02-08)
Reviewed
Tam, PPL  (2023-05-03)
Created
May, B  (2023-02-08)
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