Expression of PRDM1 in primordial germ cells

Stable Identifier
R-HSA-9827872
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of PRDM1 in primordial germ cells
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PR domain zinc finger protein 1 (PRDM1, also called BLIMP1) is expressed during specification of human PGCs in vitro (Irie et al. 2015, Sasaki et al. 2015, Kojima et al. 2017, Fang et al. 2020, Kojima et al. 2021, Tang et al. 2022). Expression of SOX17 precedes expression of PRDM1 (Irie et al. 2015). TFAP2C also acts upstream of PRDM1, unlike the case in mice (Kojima et al. 2017). SOX17 and TFAP2C bind the PRDM1 gene and activate expression during specification of PGCs in vitro (Kojima et al. 2017, Tang et al. 2022). PRDM1 functions primarily as a transcription repressor to repress somatically expressed genes (Irie et al. 2015, Sasaki et al. 2015, Tang et al. 2022).
Literature References
PubMed ID Title Journal Year
26189426 Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells

Sekiguchi, K, Moritoki, Y, Ohta, H, Kurimoto, K, Yamamoto, T, Nakagawa, M, Yamanaka, S, Mori, T, Saitou, M, Tsuchiya, H, Takahashi, K, Okamoto, I, Yamamoto, T, Woltjen, K, Sakuma, T, Yokobayashi, S, Sasaki, K, Iwatani, C, Nakamura, S, Yabuta, Y, Nakamura, T

Cell Stem Cell 2015
28985527 Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells

Saitou, M, Nakaki, F, Yamamoto, T, Woltjen, K, Yokobayashi, S, Hotta, A, Sasaki, K, Kojima, Y, Sakai, Y, Nagaoka, S, Yabuta, Y, Nakamura, T

Cell Stem Cell 2017
33608411 GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program

Saitou, M, Tsuchiya, H, Murase, Y, Okamoto, I, Yamashiro, C, Yamamoto, T, Nakaya, M, Iwatani, C, Kojima, Y, Tsukiyama, T, Yabuta, Y, Nakamura, T

Life Sci Alliance 2021
25543152 SOX17 is a critical specifier of human primordial germ cell fate

Dietmann, S, Surani, MA, Viukov, S, Tang, WW, Hanna, JH, Weinberger, L, Manor, YS, Kobayashi, T, Irie, N

Cell 2015
32127035 Analysis of multi-lineage gene expression dynamics during primordial germ cell induction from human induced pluripotent stem cells

Zhao, Q, Fang, F, Ni, K, Xiong, C, Li, Z

Stem Cell Res Ther 2020
35411086 Sequential enhancer state remodelling defines human germline competence and specification

Castillo-Venzor, A, Tang, WWC, Surani, MA, Sun, D, Gruhn, WH, Penfold, CA, Kobayashi, T, Irie, N, Morgan, MD

Nat Cell Biol 2022
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
SOX17:TFAP2C:PRDM1 gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2023-02-08)
Reviewed
Tam, PPL  (2023-05-03)
Created
May, B  (2023-02-08)
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