SOX17 and TFAP2C bind the TFAP2C gene

Stable Identifier
R-HSA-9827870
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SOX17 and TFAP2C bind the TFAP2C gene
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Expression of transcription factor AP-2 gamma (TFAP2C) is initially activated by BMP4 signaling (Kojima et al. 2017) and expression of SOX17 is initially activated by WNT signaling acting via Eomesoderm (EOMES) (Chen et al. 2017, Kojima et al. 2017). After the initial activations, SOX17 and TFAP2C together bind a large number of genetic loci including TFAP2C itself (Tang et al. 2022). SOX17 and TFAP2C maintain expression of TFAP2C during subsequent differentiation of PGCs (Tang et al. 2022)
Literature References
PubMed ID Title Journal Year
35411086 Sequential enhancer state remodelling defines human germline competence and specification

Castillo-Venzor, A, Tang, WWC, Surani, MA, Sun, D, Gruhn, WH, Penfold, CA, Kobayashi, T, Irie, N, Morgan, MD

Nat Cell Biol 2022
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Authored
May, B  (2023-02-08)
Reviewed
Tam, PPL  (2023-05-03)
Created
May, B  (2023-02-08)
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