Expression of TFAP2C in primordial germ cells

Stable Identifier
R-HSA-9827867
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of TFAP2C in primordial germ cells
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BMP4 signaling initiates expression of transcription factor AP-2 gamma (TFAP2C) (Irie et al. 2015, Sasaki et al. 2015, Fang et al. 2020, Tang et al. 2022) independently of SOX17 (Kojima et al. 2017) in human primordial germ cells (PGCs) differentiated in vitro. BMP signaling activates phosphorylation of SMAD1, SMAD5, and SMAD8, but whether any of these SMADs bind the TFAP2C promoter is not known. SOX17 and TFAP2C maintain expression of TFAP2C in differentiating PGCs (Kojima et al. 2017, Tang et al. 2022).
Literature References
PubMed ID Title Journal Year
26189426 Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells

Sekiguchi, K, Moritoki, Y, Ohta, H, Kurimoto, K, Yamamoto, T, Nakagawa, M, Yamanaka, S, Mori, T, Saitou, M, Tsuchiya, H, Takahashi, K, Okamoto, I, Yamamoto, T, Woltjen, K, Sakuma, T, Yokobayashi, S, Sasaki, K, Iwatani, C, Nakamura, S, Yabuta, Y, Nakamura, T

Cell Stem Cell 2015
28985527 Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells

Saitou, M, Nakaki, F, Yamamoto, T, Woltjen, K, Yokobayashi, S, Hotta, A, Sasaki, K, Kojima, Y, Sakai, Y, Nagaoka, S, Yabuta, Y, Nakamura, T

Cell Stem Cell 2017
25543152 SOX17 is a critical specifier of human primordial germ cell fate

Dietmann, S, Surani, MA, Viukov, S, Tang, WW, Hanna, JH, Weinberger, L, Manor, YS, Kobayashi, T, Irie, N

Cell 2015
32127035 Analysis of multi-lineage gene expression dynamics during primordial germ cell induction from human induced pluripotent stem cells

Zhao, Q, Fang, F, Ni, K, Xiong, C, Li, Z

Stem Cell Res Ther 2020
35411086 Sequential enhancer state remodelling defines human germline competence and specification

Castillo-Venzor, A, Tang, WWC, Surani, MA, Sun, D, Gruhn, WH, Penfold, CA, Kobayashi, T, Irie, N, Morgan, MD

Nat Cell Biol 2022
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
SOX17:TFAP2C:TFAP2C gene [nucleoplasm] (Homo sapiens)
Regulator
BMP4 dimer [extracellular region] (Homo sapiens)
Authored
May, B  (2023-02-08)
Reviewed
Tam, PPL  (2023-05-03)
Created
May, B  (2023-02-08)
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