Expression of CBFA2T2 in primordial germ cells

Stable Identifier
R-HSA-9827864
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of CBFA2T2 in primordial germ cells
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During differentiation of human primordial germ cells from embryonic stem cells in vitro, SOX17 and TFAP2C bind and activate transcription of the CBFA2T2 gene (Tang et al. 2022). In mice, Cbfa2t2 encodes a corepressor that interacts with Pou5f1 (Oct4) and Prdm1 and is required for differentiation of germ cells (Nady et al. 2015, Tu et al. .2016).
Literature References
PubMed ID Title Journal Year
35411086 Sequential enhancer state remodelling defines human germline competence and specification

Tang, WWC, Castillo-Venzor, A, Gruhn, WH, Kobayashi, T, Penfold, CA, Morgan, MD, Sun, D, Irie, N, Surani, MA

Nat Cell Biol 2022
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
SOX17:TFAP2C:CBFA2T2 gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2023-02-08)
Reviewed
Tam, PPL  (2023-05-03)
Created
May, B  (2023-02-08)
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