SOX17 and TFAP2C bind the CBFA2T2 gene

Stable Identifier
R-HSA-9827862
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SOX17 and TFAP2C bind the CBFA2T2 gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SOX17 and TFAP2C bind the gene encoding CBFA2T2 (also called MTGR1) during differentiation of human primordial germ cells from embryonic stem cells in vitro (Tang et al. 2022). In mice Cbfa2t2 is a transcriptional co-repressor that interacts with Oct4 and Prdm14 to regulate pluripotency and germ line differentiation (Nady et al. 2015, Tu et al. 2016).
Literature References
PubMed ID Title Journal Year
35411086 Sequential enhancer state remodelling defines human germline competence and specification

Castillo-Venzor, A, Tang, WWC, Surani, MA, Sun, D, Gruhn, WH, Penfold, CA, Kobayashi, T, Irie, N, Morgan, MD

Nat Cell Biol 2022
Participants
Input
Output
Participates
as an event of
Authored
May, B  (2023-02-08)
Reviewed
Tam, PPL  (2023-05-03)
Created
May, B  (2023-02-08)
Cite Us!