MITF-M dimer and the SWI/SNF complex bind the TYRP1 promoter

Stable Identifier
R-HSA-9825847
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M dimer and the SWI/SNF complex bind the TYRP1 promoter
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MITF-M binds to the promoter of the TYRP1 gene to stimulate expression as assessed by reporter gene assay, electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP) (Bertolotto et al, 1998a, b; Fang et al, 2002; De la Serna et al, 2006; reviewed in Cheli et al, 2010). Promoter recognition is mediated by an M-box (located between position -49 and -39 in human, -44 and -33 in mouse) and a related E-box (position -238 to -233 in mouse) (Bertolotto et al, 1998a; Fang et al, 2002). Expression is also stimulated by the MITF-M-dependent recruitment of a SWI/SNF complex as assessed by co-immunoprecipitation of SMARCA4 (BRG1), SMARCE1 (INI1) and SMARCB1 (BAF57) in mouse, and in an additional study with SMARCD1 (de la Serna et al, 2006; Keenen et al, 2010; Aras et al, 2019).
Literature References
PubMed ID Title Journal Year
19784067 Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma

Keenen, B, Qi, H, Saladi, SV, Yeung, M, de la Serna, IL

Oncogene 2010
19995375 Fifteen-year quest for microphthalmia-associated transcription factor target genes

Cheli, Y, Ohanna, M, Ballotti, R, Bertolotto, C

Pigment Cell Melanoma Res 2010
9700169 Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes

Bertolotto, C, Abbe, P, Hemesath, TJ, Bille, K, Fisher, DE, Ortonne, JP, Ballotti, R

J Cell Biol 1998
16648630 The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes

de la Serna, IL, Ohkawa, Y, Higashi, C, Dutta, C, Osias, J, Kommajosyula, N, Tachibana, T, Imbalzano, AN

J Biol Chem 2006
30515787 BAF60A mediates interactions between the microphthalmia-associated transcription factor and the BRG1-containing SWI/SNF complex during melanocyte differentiation

Aras, S, Saladi, SV, Basuroy, T, Marathe, HG, Lorès, P, de la Serna, IL

J Cell Physiol 2019
12136092 Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF

Fang, D, Tsuji, Y, Setaluri, V

Nucleic Acids Res 2002
9447965 Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia

Bertolotto, C, Buscà, R, Abbe, P, Bille, K, Aberdam, E, Ortonne, JP, Ballotti, R

Mol Cell Biol 1998
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Authored
Rothfels, K  (2023-01-26)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2023-01-27)
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