MITF-M dimer binds MLANA gene

Stable Identifier
R-HSA-9825844
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M dimer binds MLANA gene
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MITF-M binds to an E-box site at position -609 in the promoter of the MLANA gene to upregulate expression as assessed by ChIP, EMSA, reporter gene assay and Northern analysis (Du et al, 2003; Strub et al, 2011; reviewed in Cheli et al, 2010).
Literature References
PubMed ID Title Journal Year
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Strub, T, Giuliano, S, Ye, T, Bonet, C, Keime, C, Kobi, D, Le Gras, S, Cormont, M, Ballotti, R, Bertolotto, C, Davidson, I

Oncogene 2011
19995375 Fifteen-year quest for microphthalmia-associated transcription factor target genes

Cheli, Y, Ohanna, M, Ballotti, R, Bertolotto, C

Pigment Cell Melanoma Res 2010
12819038 MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma

Du, J, Miller, AJ, Widlund, HR, Horstmann, MA, Ramaswamy, S, Fisher, DE

Am J Pathol 2003
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Authored
Rothfels, K  (2023-01-26)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2023-01-27)
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