MITF-M-dependent TBX2 gene expression

Stable Identifier
R-HSA-9825840
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M-dependent TBX2 gene expression
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TBX2 is an MITF-M-dependent target that contributes to melanocyte fate determination and cellular proliferation (Carreira et al, 1998; Carreira et al, 2000; reviewed in Abrahams et al, 2010; Cheli et al, 2010). TBX2 is a member of the T-box family of transcription factors and in the context of melanocyte differentiation, controls expression of target genes such as TYRP1 and CCCND1, and represses expression of the cell cycle inhibitors CDKN1A (p21) and the CDKN2A gene protein produce p14ARF (p19ARF in mouse) (Carreira et al, 1998; Carreira et al, 2000; Sarangarajan et al, 2000; Pan et al, 2015; Jacobs et al, 2000; Prince et al, 2004; Vance et al, 2005; reviewed in Cheli et al, 2010).
Literature References
PubMed ID Title Journal Year
10770922 The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes

Liu, B, Goding, CR, Carreira, S

J Biol Chem 2000
11041210 Mutant alleles at the brown locus encoding tyrosinase-related protein-1 (TRP-1) affect proliferation of mouse melanocytes in culture

Babcock, G, Sarangarajan, R, Boissy, RE, Zhao, Y, Lamoreux, ML, Cornelius, J

Pigment Cell Res 2000
9710594 Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter

Easty, DJ, Goding, CR, Dexter, TJ, Yavuzer, U, Carreira, S

Mol Cell Biol 1998
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Ye, T, Cormont, M, Keime, C, Kobi, D, Davidson, I, Le Gras, S, Giuliano, S, Bonet, C, Bertolotto, C, Ballotti, R, Strub, T

Oncogene 2011
14996726 Tbx2 directly represses the expression of the p21(WAF1) cyclin-dependent kinase inhibitor

Prince, S, Abrahams, A, Carreira, S, Vance, KW, Goding, CR

Cancer Res 2004
19995375 Fifteen-year quest for microphthalmia-associated transcription factor target genes

Bertolotto, C, Cheli, Y, Ohanna, M, Ballotti, R

Pigment Cell Melanoma Res 2010
11062467 Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers

van de Vijver, MJ, van Welsem, T, Kristel, P, Keblusek, P, Jacobs, JJ, Robanus-Maandag, E, Nederlof, PM, Koh, EY, Lingbeek, M, Daley, GQ, van Lohuizen, M

Nat Genet 2000
15781639 Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas

Carreira, S, Vance, KW, Goding, CR, Brosch, G

Cancer Res 2005
26486273 Microphthalmia-associated transcription factor/T-box factor-2 axis acts through Cyclin D1 to regulate melanocyte proliferation

Chen, Y, Ma, X, Wen, B, Qu, J, Li, H, Liu, Y, Pan, L, Zheng, X, Lu, F, Wang, J, Su, Z, Hou, L

Cell Prolif 2015
19960541 The T-box transcription factor Tbx2: its role in development and possible implication in cancer

Prince, S, Abrahams, A, Parker, MI

IUBMB Life 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MITF-M:TBX2 gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Rothfels, K  (2023-01-26)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2023-01-27)
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