MITF-M-dependent CDKN1A expression

Stable Identifier
R-HSA-9825837
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M-dependent CDKN1A expression
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MITF-dependent expression of CDKN1A is associated with cell cycle arrest and initiation of the MITF-dependent differentiation and pigmentation process (Carreira et al, 2005; Carreira et al, 2006; reviewed in Cheli et al, 2010; Goding and Arnheiter, 2019). In mouse embryonic fibroblasts, NIH3T3 cells and RAT1 cells, overexpression of MITF results in CDKN1A-dependent cell cycle arrest (Carreira et al, 2005). Despite this, the precise role of CDKN1A during development of the melanocyte lineage is unclear, as CDKN1A-deficient mice show no loss of pigmentation, while MITF in conjunction with BCL2 is essential for melanoblast survival (Deng et al, 1995; Hornyak et al, 2003; McGill et al, 2002; Hodgkinson et al, 1993; reviewed in Goding and Arnheiter, 2019; White and Zon, 2015)
Literature References
PubMed ID Title Journal Year
12086670 Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

McGill, GG, Horstmann, M, Widlund, HR, Du, J, Motyckova, G, Nishimura, EK, Lin, YL, Ramaswamy, S, Avery, W, Ding, HF, Jordan, SA, Jackson, IJ, Korsmeyer, SJ, Golub, TR, Fisher, DE

Cell 2002
8343963 Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein

Hodgkinson, CA, Moore, KJ, Nakayama, A, Steingrìmsson, E, Copeland, NG, Jenkins, NA, Arnheiter, H

Cell 1993
17182868 Mitf regulation of Dia1 controls melanoma proliferation and invasiveness

Carreira, S, Goodall, J, Denat, L, Rodriguez, M, Nuciforo, P, Hoek, KS, Testori, A, Larue, L, Goding, CR

Genes Dev 2006
19995375 Fifteen-year quest for microphthalmia-associated transcription factor target genes

Cheli, Y, Ohanna, M, Ballotti, R, Bertolotto, C

Pigment Cell Melanoma Res 2010
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
11231058 Transcription factors in melanocyte development: distinct roles for Pax-3 and Mitf

Hornyak, TJ, Hayes, DJ, Chiu, LY, Ziff, EB

Mech Dev 2001
7664346 Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.

Deng, C, Zhang, P, Harper, JW, Elledge, SJ, Leder, P

Cell 1995
15716956 Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression

Carreira, S, Goodall, J, Aksan, I, La Rocca, SA, Galibert, MD, Denat, L, Larue, L, Goding, CR

Nature 2005
18786412 Melanocytes in development, regeneration, and cancer

White, RM, Zon, LI

Cell Stem Cell 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:CDKN1A gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Rothfels, K  (2023-01-26)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2023-01-27)
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