p-S742 TBX3 binds CDH1 promoter

Stable Identifier
R-HSA-9825794
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-S742 TBX3 binds CDH1 promoter
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TBX3 binds to the promoter of the CDH1 gene to repress its transcription as assessed by electrophoretic mobility shift assay (EMSA), chromatin immunoprecipitation, reporter gene assays and RT-PCR (Rodriguez et al, 2008). AKT3-dependent phosphorylation of TBX3 promotes its nuclear localization, enhances its repression activity towards CDH1 and may increase its DNA binding affinity (Peres et al, 2015; Peres et al, 2021). TBX3 is overexpressed in melanoma and contributes to its migration and invasiveness, in part through regulation of CDH1 expression (Boyd et al, 2013; Peres and Prince 2013; Peres et al, 2010; Peres et al, 2017; reviewed in Khan et al, 2020).
Literature References
PubMed ID Title Journal Year
28757416 The tumour suppressor, miR-137, inhibits malignant melanoma migration by targetting the TBX3 transcription factor

Peres, J, Kwesi-Maliepaard, EM, Prince, S, Rambow, F, Larue, L

Cancer Lett 2017
23190890 Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion

Tran, SL, Becker, TM, Mann, GJ, Gowrishankar, K, Rizos, H, Scolyer, RA, Pupo, GM, Kefford, RF, Shaw, HM, Goding, CR, Mijatov, B, Boyd, SC

J Invest Dermatol 2013
21779450 The Highly Homologous T-Box Transcription Factors, TBX2 and TBX3, Have Distinct Roles in the Oncogenic Process

Bennett, DC, Peres, J, Prince, S, Davis, E, Wansleben, S, Mowla, S, Li, JA

Genes Cancer 2010
31669645 The roles and regulation of TBX3 in development and disease

Peres, J, Prince, S, Du Toit, M, Omar, R, Khan, M, Sahm, BDB, Damerell, V, Mlaza, M, Bleloch, J, Khan, SF, Maranyane, HM, ArulJothi, KN, Bellis, C

Gene 2020
25595898 The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis

Peres, J, Prince, S, Mowla, S

Oncotarget 2015
18829543 Tbx3 represses E-cadherin expression and enhances melanoma invasiveness

Aladowicz, E, Lanfrancone, L, Rodriguez, M, Goding, CR

Cancer Res 2008
24098938 The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion

Peres, J, Prince, S

Mol Cancer 2013
33744299 TBX3 Promotes Melanoma Migration by Transcriptional Activation of ID1, which Prevents Activation of E-Cadherin by MITF

Peres, J, Galibert, MD, Prince, S, Popovic, A, Goding, CR, Damerell, V, Chauhan, J, Desprez, PY

J Invest Dermatol 2021
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Authored
Rothfels, K  (2023-01-26)
Reviewed
de la Serna, IL  (2024-05-21)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2023-01-26)
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