Reactome | p-S207 KARS1 dimer translocates to the nucleus

p-S207 KARS1 dimer translocates to the nucleus

Stable Identifier

R-HSA-9825783

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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p-S207 KARS1 dimer translocates to the nucleus

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After KIT- and MAPK-stimulated phosphorylation, KARS dimer translocates to the nucleus (Yannay-Cohen et al, 2009; Ofir-Birin et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
23159739	Structural switch of lysyl-tRNA synthetase between translation and transcription Nechushtan, H, Fang, P, Yang, XL, Dagan, A, Schimmel, P, Pozo, J, Razin, E, Shapiro, R, Bennett, SP, Wang, J, Ofir-Birin, Y, Guo, M, Kim, S, Song, J, Marshall, AG, Rachmin, I, Zhang, HM	Mol Cell	2013
19524539	LysRS serves as a key signaling molecule in the immune response by regulating gene expression Kemeny, DM, Yang, CM, Razin, E, Nechushtan, H, Han, JM, Kay, G, Kim, S, Yannay-Cohen, N, Carmi-Levy, I	Mol Cell	2009