TBX3-dependent ID1 gene expression

Stable Identifier
R-HSA-9825780
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TBX3-dependent ID1 gene expression
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ID1-4 (Inhibitor of DNA-binding) are members of the helix-loop-helix family of proteins that lack the basic amino acids responsible for DNA binding in basic HLH proteins. HLH domain-mediated heterodimerization of an ID protein with a basic HLH protein therefore acts as a natural dominant negative inhibitor of bHLH function by preventing DNA binding (Massari and Murre, 2000). ID proteins primarily interact with members of the E family of proteins, including E12, E47, HEB and E2-2, but also interact with other bHLH proteins. ID proteins promote cell cycle progression and cell migration, and restrict cellular senescence and the differentiation of a number of progenitor cell types, including oligodendrocytes (reviewed in Perk et al, 2005; Ling et al, 2014). ID1 and ID3 proteins also have established roles in hematopoiesis (Nogueira et al, 2000; Rivera and Murre, 2001; Hong et al, 2011; Zhao et al, 2016).
ID1 is overexpressed in melanomas and promotes invasion and motility (Straume and Akslen, 2005; Zigler et al, 2011). ID1 may promote invasiveness in melanoma cells by binding and inhibiting MITF-dependent CDH1 expression. Consistent with this model, ID1 and MITF-M have been shown to interact in osteoclast cells (Mansky et al, 2002; Lee et al, 2006).
Literature References
PubMed ID Title Journal Year
21486943 ID1 and ID3 represent conserved negative regulators of human embryonic and induced pluripotent stem cell hematopoiesis

Hong, SH, Lee, JH, Lee, JB, Ji, J, Bhatia, M

J. Cell. Sci. 2011
25248477 Id proteins: small molecules, mighty regulators

Ling, F, Kang, B, Sun, XH

Curr. Top. Dev. Biol. 2014
21467165 Expression of Id-1 is regulated by MCAM/MUC18: a missing link in melanoma progression

Zigler, M, Villares, GJ, Dobroff, AS, Wang, H, Huang, L, Braeuer, RR, Kamiya, T, Melnikova, VO, Song, R, Friedman, R, Alani, RM, Bar-Eli, M

Cancer Res 2011
27128622 Combined Id1 and Id3 Deletion Leads to Severe Erythropoietic Disturbances

Zhao, Q, Chang, C, Gonzalez, JP, Alzahrani, K, Button, JL, Fraidenraich, D

PLoS ONE 2016
11840323 The regulation and function of the Id proteins in lymphocyte development

Rivera, R, Murre, C

Oncogene 2001
10611221 Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms

Massari, ME, Murre, C

Mol. Cell. Biol. 2000
16034366 Id family of helix-loop-helix proteins in cancer

Perk, J, Iavarone, A, Benezra, R

Nat. Rev. Cancer 2005
11818451 The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts

Mansky, KC, Marfatia, K, Purdom, GH, Luchin, A, Hume, DA, Ostrowski, MC

J Leukoc Biol 2002
16322470 Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation

Lee, J, Kim, K, Kim, JH, Jin, HM, Choi, HK, Lee, SH, Kook, H, Kim, KK, Yokota, Y, Lee, SY, Choi, Y, Kim, N

Blood 2006
16189525 Strong expression of ID1 protein is associated with decreased survival, increased expression of ephrin-A1/EPHA2, and reduced thrombospondin-1 in malignant melanoma

Straume, O, Akslen, LA

Br J Cancer 2005
11027551 Regulation of Id gene expression during embryonic stem cell-derived hematopoietic differentiation

Nogueira, MM, Mitjavila-Garcia, MT, Le Pesteur, F, Filippi, MD, Vainchenker, W, Dubart Kupperschmitt, A, Sainteny, F

Biochem. Biophys. Res. Commun. 2000
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S742 TBX3:ID1 gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S742 TBX3 [nucleoplasm]
Authored
Rothfels, K  (2023-01-26)
Reviewed
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2023-01-26)
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