SNAI2 gene expression

Stable Identifier
R-HSA-9825406
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SNAI2 gene expression
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SNAI2, also known as SLUG or SNAIL2, is a DNA-binding zinc finger transcriptional factor with roles in cellular differentiation, DNA damage repair, tumorigenesis and epithelial-mesenchymal transition (reviewed in Zhou et al, 2019). SNAI2 contributes to cell migration by repressing CDH1 (E-cadherin) (Poser et al, 2001; Li et al, 2001; Gupta et al, 2005; Bagnato et al, 2004; reviewed in Zhou et al, 2019). Changes in relative levels of E- and N-cadherin contribute to migration of neural crest cells during melanocyte differentiation, and also play a role during the development of melanoma (Li et al, 2001; Gupta et al, 2005; LaBonne et al, 2000; reviewed in Mort et al, 2015).
Literature References
PubMed ID Title Journal Year
11323412 Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail

Buettner, R, Domínguez, D, Bosserhoff, AK, de Herreros, AG, Poser, I, Varnai, A

J Biol Chem 2001
16142232 The melanocyte differentiation program predisposes to metastasis after neoplastic transformation

Gupta, PB, Weinberg, RA, Brunet, JP, Ramaswamy, S, Naber, SP, Kuperwasser, C, Gray, JW, Kuo, WL

Nat Genet 2005
11325858 N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells

Li, G, Satyamoorthy, K, Herlyn, M

Cancer Res 2001
10772801 Snail-related transcriptional repressors are required in Xenopus for both the induction of the neural crest and its subsequent migration

Bronner-Fraser, M, LaBonne, C

Dev Biol 2000
25670789 The melanocyte lineage in development and disease

Jackson, IJ, Patton, EE, Mort, RL

Development 2015
31792043 Molecular regulation of Snai2 in development and disease

Zhou, W, Kuperwasser, C, Gross, KM

J Cell Sci 2019
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Authored
Rothfels, K  (2023-01-26)
Reviewed
de la Serna, IL  (2024-05-21)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2023-01-26)
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