Reactome | XPO1-dependent export of p-S69,S73 MITF-M

XPO1-dependent export of p-S69,S73 MITF-M

Stable Identifier

R-HSA-9824986

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

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XPO1-dependent export of p-S69,S73 MITF-M

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After binding XPO1 (CRM1), MITF-M is exported to the cytosol (Ngeow et al, 2018). In addition to XPO1, MITF-M also interacts with numerous other proteins invovled in nuclear export, as assessed by TAP tagging and mass spectrometry studies (Laurette et al, 2015).

Literature References

PubMed ID	Title	Journal	Year
25803486	Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells Cornell, RA, Koludrovic, D, Imrichova, H, Aerts, S, Siddaway, R, Mengus, G, Keime, C, Seberg, H, Laurette, P, Van Otterloo, E, Le Gras, S, Davidson, I, Strub, T	Elife	2015
30150413	BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export Knapp, S, Patton, EE, Friedrichsen, HJ, Berridge, G, Filippakopoulos, P, Andrews, S, Fischer, R, Goding, CR, Picaud, S, Brunsdon, H, Ngeow, KC, Borden, KLB, Zeng, Z, Steingrímsson, E, Lisle, R, Knowles, H, Volpon, L, Li, L	Proc Natl Acad Sci U S A	2018