MITF-M and the SWI/SNF complex bind the TYR promoter

Stable Identifier
R-HSA-9824981
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M and the SWI/SNF complex bind the TYR promoter
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As assessed by electrophoretic mobility shift assay (EMSA) and chromatin immunopreciptitation (ChIP), MITF-M binds to an M-box element at position-115 and to the related E-box element at the transcriptional start site of the TYR gene to activate transcription (Bentley et al, 1994; Takeda et al, 1998; Galibert et al, 2001; Strub et al, 2011). Some studies have demonstrated that MITF-M binding to the TYR promoter is constitutive and drives basal expression, with UV-inducible expression being driven by the basic helix loop helix protein USF1 downstream of p38 signaling (Bentley et al, 1994; Galibert et al, 2001). MITF-M also recruits the SWI/SNF complex to the promoter, as demonstrated through co-immunoprecipitation of MITF with the SWI/SNF components SMARCA4, SMARCA2, SMARCE1, SMARCB1 and in an additional study, with SMARCD1 and SMARCD2 (de la Serna et al, 2006; Keenaen et al, 2010; Aras et al, 2019). In 501MEL melanoma cells, MITF interacts with the PBAF chromatin remodelling complex containing SMARCA4, PBRM1, SMARCC1, SMARCD2, ACTL6A and CHD7 (Laurette et al, 2015).
Literature References
PubMed ID Title Journal Year
7969139 Melanocyte-specific expression of the human tyrosinase promoter: activation by the microphthalmia gene product and role of the initiator

Bentley, NJ, Eisen, T, Goding, CR

Mol Cell Biol 1994
25803486 Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

Laurette, P, Strub, T, Koludrovic, D, Keime, C, Le Gras, S, Seberg, H, Van Otterloo, E, Imrichova, H, Siddaway, R, Aerts, S, Cornell, RA, Mengus, G, Davidson, I

Elife 2015
19784067 Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma

Keenen, B, Qi, H, Saladi, SV, Yeung, M, de la Serna, IL

Oncogene 2010
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Strub, T, Giuliano, S, Ye, T, Bonet, C, Keime, C, Kobi, D, Le Gras, S, Cormont, M, Ballotti, R, Bertolotto, C, Davidson, I

Oncogene 2011
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
16648630 The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes

de la Serna, IL, Ohkawa, Y, Higashi, C, Dutta, C, Osias, J, Kommajosyula, N, Tachibana, T, Imbalzano, AN

J Biol Chem 2006
30515787 BAF60A mediates interactions between the microphthalmia-associated transcription factor and the BRG1-containing SWI/SNF complex during melanocyte differentiation

Aras, S, Saladi, SV, Basuroy, T, Marathe, HG, Lorès, P, de la Serna, IL

J Cell Physiol 2019
11532965 The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression

Galibert, MD, Carreira, S, Goding, CR

EMBO J 2001
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Inferred From
Mitf-m binds Smarca4, Smarcb1, Smarce1, Smarcd1 (Mus musculus)
Authored
Rothfels, K  (2023-01-26)
Reviewed
Arnheiter, H  (2024-03-01)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2023-01-23)
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