MITF-M-dependent MET gene expression

Stable Identifier
R-HSA-9824597
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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MITF-M-dependent MET gene expression
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MET gene expression is activated downstream of active MITF in normal primary human melanocytes and in melanomas (reviewed in Cheli et al, 2010; Gentile el al 2008; Goding and Arnheiter, 2019). MITF-dependent MET gene expression is responsive to increased cAMP levels downstream of UV-induced alpha-MSH production, and has also been demonstrated in response to HGF (McGill et al, 2006; Beuret et al, 2007; Mascarenhas et al, 2010; reviewed in Cheli et al, 2010). MET expression contributes to the survival and proliferation of melanocytes and melanoma (Kos et al, 1999; Kunisada et al, 2000; Natali et al 1993; Puri et al, 2007; Saitoh et al, 1994; reviewed in Gentile et al, 2008; Cheli et al, 2010; Goding and Arnheiter, 2019).
Literature References
PubMed ID Title Journal Year
8104462 Expression of the c-Met/HGF receptor in human melanocytic neoplasms: demonstration of the relationship to malignant melanoma tumour progression

Natali, PG, Nicotra, MR, Di Renzo, MF, Prat, M, Bigotti, A, Cavaliere, R, Comoglio, PM

Br J Cancer 1993
20067553 PAX3 and SOX10 activate MET receptor expression in melanoma

Mascarenhas, JB, Littlejohn, EL, Wolsky, RJ, Young, KP, Nelson, M, Salgia, R, Lang, D

Pigment Cell Melanoma Res 2010
17404109 c-Met is a potentially new therapeutic target for treatment of human melanoma

Puri, N, Ahmed, S, Janamanchi, V, Tretiakova, M, Zumba, O, Krausz, T, Jagadeeswaran, R, Salgia, R

Clin Cancer Res 2007
17371876 Up-regulation of MET expression by alpha-melanocyte-stimulating hormone and MITF allows hepatocyte growth factor to protect melanocytes and melanoma cells from apoptosis

Beuret, L, Flori, E, Denoyelle, C, Bille, K, Busca, R, Picardo, M, Bertolotto, C, Ballotti, R

J Biol Chem 2007
16455654 c-Met expression is regulated by Mitf in the melanocyte lineage

McGill, GG, Haq, R, Nishimura, EK, Fisher, DE

J Biol Chem 2006
19995375 Fifteen-year quest for microphthalmia-associated transcription factor target genes

Cheli, Y, Ohanna, M, Ballotti, R, Bertolotto, C

Pigment Cell Melanoma Res 2010
18175071 The Met tyrosine kinase receptor in development and cancer

Gentile, A, Trusolino, L, Comoglio, PM

Cancer Metastasis Rev 2008
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
10842060 Keratinocyte expression of transgenic hepatocyte growth factor affects melanocyte development, leading to dermal melanocytosis

Kunisada, T, Yamazaki, H, Hirobe, T, Kamei, S, Omoteno, M, Tagaya, H, Hemmi, H, Koshimizu, U, Nakamura, T, Hayashi, SI

Mech Dev 2000
10193678 Hepatocyte growth factor/scatter factor-MET signaling in neural crest-derived melanocyte development

Kos, L, Aronzon, A, Takayama, H, Maina, F, Ponzetto, C, Merlino, G, Pavan, W

Pigment Cell Res 1999
7823252 Detection of the c-met proto-oncogene product in normal skin and tumours of melanocytic origin

Saitoh, K, Takahashi, H, Sawada, N, Parsons, PG

J Pathol 1994
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:MET gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Rothfels, K  (2023-01-26)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2023-01-20)
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