MITF-M-dependent TYRP1 gene expression

Stable Identifier
R-HSA-9824593
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, melanosome membrane
ReviewStatus
5/5
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MITF-M-dependent TYRP1 gene expression
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The TYRP1 gene encodes 5,6-dihydroxyindole-2-carboxylic acid oxidase. TYRP1 has cAMP-responsive M- and E- box elements in its promoter that are bound by MIITF-M as demonstrated by ChIP and EMSA in mouse and human cells. Transcriptional activity at the TYRP1 promoter is enhanced by the MITF-M-dependent recruitment of a SWI/SNF complex containing SMARCA4 (BRG1), SMARCE1 (BAF57) and SMARCB1 (INI1) (Bertolotto et al, 1996; Bertolotto et al, 1998 a,b; De La Serna et al, 2006; reviewed in Goding, 2000; Cheli et al, 2010; Goding and Arheiter, 2019).
The role of TYRP1 in melanin biosynthesis is somewhat ambiguous. Purified mouse TYRP1 has been shown to catalyze the oxidation of the melanin intermediate DHICA (5,6-dihydroxyindole-2-carboxylic acid) to form melanins, however this activity has not been reproduced with the human protein (Jimenez-Cervantes et al, 1994; Kobayashi et al, 1994; Boissy et al, 1998). Other models suggest that TYRP1 may play a role as a chaperone for TYR or as a buffer against melanin toxicity, however definitive evidence for these or other roles remain to be determined (Kobayashi et al, 1998; Johnson and Jackson, 1992; Luo et al, 1994; Rad et al, 2004; reviewed in Le et al, 2021)
Literature References
PubMed ID Title Journal Year
15265682 Tyrosinase-related proteins suppress tyrosinase-mediated cell death of melanocytes and melanoma cells

Jimbow, K, Hirosaki, K, Yamashita, T, Wakamatsu, K, Jin, HY, Ito, S, Rad, HH

Exp Cell Res 2004
34021746 Melanosome Biogenesis in the Pigmentation of Mammalian Skin

Delevoye, C, Raposo, G, Le, L, Sirés-Campos, J, Marks, MS

Integr Comp Biol 2021
19995375 Fifteen-year quest for microphthalmia-associated transcription factor target genes

Bertolotto, C, Cheli, Y, Ohanna, M, Ballotti, R

Pigment Cell Melanoma Res 2010
31123060 MITF-the first 25 years

Arnheiter, H, Goding, CR

Genes Dev 2019
8020595 Cotransfection of genes encoding human tyrosinase and tyrosinase-related protein-1 prevents melanocyte death and enhances melanin pigmentation and gene expression of Lamp-1

Jimbow, K, Chen, H, Luo, D

Exp Cell Res 1994
16648630 The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes

Osias, J, Kommajosyula, N, Tachibana, T, Dutta, C, de la Serna, IL, Ohkawa, Y, Imbalzano, AN, Higashi, C

J Biol Chem 2006
9447965 Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia

Abbe, P, Bille, K, Ballotti, R, Bertolotto, C, Ortonne, JP, Buscà, R, Aberdam, E

Mol Cell Biol 1998
1303241 Light is a dominant mouse mutation resulting in premature cell death

Johnson, R, Jackson, IJ

Nat Genet 1992
9822646 Tyrosinase stabilization by Tyrp1 (the brown locus protein)

Hearing, VJ, Imokawa, G, Kobayashi, T, Bennett, DC

J Biol Chem 1998
7813420 Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis

Hearing, VJ, Jiménez-Cervantes, C, Winder, A, Brewington, T, Imokawa, G, Kobayashi, T, Solano, F, Urabe, K, García-Borrón, JC

EMBO J. 1994
8707852 Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product

Bille, K, Ballotti, R, Bertolotto, C, Ortonne, JP

J Cell Biol 1996
8027058 A new enzymatic function in the melanogenic pathway. The 5,6-dihydroxyindole-2-carboxylic acid oxidase activity of tyrosinase-related protein-1 (TRP1)

Hearing, VJ, Jiménez-Cervantes, C, Lozano, JA, Kobayashi, T, Solano, F, Urabe, K, García-Borrón, JC

J Biol Chem 1994
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Ye, T, Cormont, M, Keime, C, Kobi, D, Davidson, I, Le Gras, S, Giuliano, S, Bonet, C, Bertolotto, C, Ballotti, R, Strub, T

Oncogene 2011
9700169 Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes

Hemesath, TJ, Abbe, P, Bille, K, Ballotti, R, Bertolotto, C, Fisher, DE, Ortonne, JP

J Cell Biol 1998
10898786 Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage

Goding, CR

Genes Dev 2000
9758418 Human tyrosinase related protein-1 (TRP-1) does not function as a DHICA oxidase activity in contrast to murine TRP-1

Hearing, VJ, Boissy, RE, Kobayashi, T, Zhao, H, Sakai, C

Exp. Dermatol. 1998
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:BAF complex:TYRP1 gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Rothfels, K  (2023-01-26)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2023-01-20)
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