Expression of HES7 in presomitic mesoderm

Stable Identifier
R-HSA-9824268
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of HES7 in presomitic mesoderm
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The NOTCH1 intracellular domain (NICD from NOTCH signaling) complexed with RBPJ, LEF1:CTNNB1 from WNT signaling, and TBX6 activate expression of the transcription repressor HES7 specifically in presomitic mesoderm (inferred from mouse homologs). HES7 represses its own expression by binding E-box sequences in its promoter, which causes oscillatory expression during somitogenesis (inferred from the mouse homolog).
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
HES7:LEF1:CTNNB1:TBX6:RBPJ:NICD1:HES7 gene [nucleoplasm] (Homo sapiens)
Positively by
Regulator
LEF1:CTNNB1:TBX6:RBPJ:NICD1:HES7 gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Hes7 in presomitic mesoderm (Mus musculus)
Authored
Chalamalasetty, RB  (2022-11-09)
Yamaguchi, TP  (2022-11-09)
Reviewed
May, B  (2023-05-12)
Created
May, B  (2023-01-18)
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