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RBPJ:NICD1 and MSGN1 bind the LFNG gene
Stable Identifier
R-HSA-9824182
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RBPJ:NICD1 and MSGN1 bind the LFNG gene (Homo sapiens)
General
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SBGN
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Mesogenin1 (MSGN1) binds the upstream regulatory region of the Lunatic fringe (LFNG) gene (inferred from mouse homologs). MSGN1 binds both the block A conserved promoter element that regulates expression in the posterior presomitic mesoderm and the block B conserved element that regulates expression in the anterior presomitic mesoderm (inferred from mouse homologs). RBPJ and the Notch intracellular domain (NICD) fragment produced by NOTCH1 signaling bind the block A conserved element (inferred from mouse homologs).
Participants
Input
LFNG gene [nucleoplasm]
(Homo sapiens)
MSGN1 [nucleoplasm]
(Homo sapiens)
RBPJ:NICD1 [nucleoplasm]
(Homo sapiens)
Output
RBPJ:NICD1:MSGN1:LFNG gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Somitogenesis (Homo sapiens)
Inferred From
Rbpj:Nicd and Msgn1 bind the Lfng gene (Mus musculus)
Authored
Chalamalasetty, RB (2022-11-09)
Yamaguchi, TP (2022-11-09)
Reviewed
May, B (2023-05-12)
Created
May, B (2023-01-18)
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