Expression of E-cadherin (CDH1) in definitive endoderm

Stable Identifier
R-HSA-9823995
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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Expression of E-cadherin (CDH1) in definitive endoderm
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E-cadherin (CDH1), an epithelial adhesion protein, is expressed throughout the epiblast, and is downregulated in nascent mesoderm during the epithelial to mesenchymal transition in early gastrulation, and upregulated in definitive endoderm at mid-gastrulation (inferred from mouse embryos). CDH1 expressed in definitive endoderm (DE) is hypothesized to participate in sorting DE from mesoderm (inferred from mouse embryos). MIXL1, in the primitive streak, and SOX17, in the endoderm, activate expression of CDH1 (inferred from mouse homologs).
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Output
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as an event of
This event is regulated
Positively by
Regulator
MIXL1 [nucleoplasm] (Homo sapiens)
Regulator
SOX17 [nucleoplasm] (Homo sapiens)
Inferred From
Expression of E-cadherin (Cdh1) in definitive endoderm (Mus musculus)
Authored
May, B  (2023-01-11)
Reviewed
Tam, PPL  (2023-02-28)
Salehin, N  (2023-02-28)
Created
May, B  (2023-01-13)
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