Expression of GSC in definitive endoderm

Stable Identifier
R-HSA-9823992
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of GSC in definitive endoderm
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During gastrulation in mice, Goosecoid (Gsc) is expressed at the anterior end of the primitive streak (Blum et al. 1992) then in the foregut endoderm (Belo et al. 1998). MIXL1 binds elements in the upstream promoter of the GSC gene and activates transcription (inferred from mouse homologs). High NODAL signaling in the anterior primitive streak activates expression of GSC (Xu et al. 2011) through the phosphorylation of SMAD2 and SMAD3, which bind together with SMAD4 at the GSC promoter and activate transcription (inferred from human pluripotent stem cells in Brown et al. 2011, Teo et al. 2011, Danehvar et al. 2016). BMP signaling reduces the expression of GSC (Xu et al. 2011).
Literature References
PubMed ID Title Journal Year
21630377 Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors

Brown, S, Teo, A, Pauklin, S, Hannan, N, Cho, CH, Lim, B, Vardy, L, Dunn, NR, Trotter, M, Pedersen, R, Vallier, L

Stem Cells 2011
21855631 Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells

Xu, X, Browning, VL, Odorico, JS

Mech Dev 2011
21245162 Pluripotency factors regulate definitive endoderm specification through eomesodermin

Teo, AK, Arnold, SJ, Trotter, MW, Brown, S, Ang, LT, Chng, Z, Robertson, EJ, Dunn, NR, Vallier, L

Genes Dev. 2011
27705785 DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells

Daneshvar, K, Pondick, JV, Kim, BM, Zhou, C, York, SR, Macklin, JA, Abualteen, A, Tan, B, Sigova, AA, Marcho, C, Tremblay, KD, Mager, J, Choi, MY, Mullen, AC

Cell Rep 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
EOMES:p-2S-SMAD2,3:SMAD4:MIXL1:GSC gene [nucleoplasm] (Homo sapiens)
Regulator
DIGIT lncRNA [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Gsc in definitive endoderm (Mus musculus)
Authored
May, B  (2023-01-11)
Reviewed
Salehin, N  (2023-02-28)
Tam, PPL  (2023-02-28)
Created
May, B  (2023-01-13)
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