Expression of GATA6 in definitive endoderm

Stable Identifier
R-HSA-9823977
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of GATA6 in definitive endoderm
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In mouse embryos, Gata6 is expressed in the primitive streak and continues expression in the definitive endoderm (Morrisey et al. 1996, Freyer et al. 2015, Wen et al. 2017). In human embryonic stem cell models, GATA6 is required for formation of definitive endoderm and pancreas development (Tiyaboonchai et al.2017, Chia et al. 2019). In the definitive endoderm, NODAL signaling activates transcription of GATA6 via the phosphorylation of SMAD2 and SMAD3, which bind the GATA6 promoter (inferred from human pluripotent stem cells in McLean et al. 2007, Vallier et al. 2009, Brown et al. 2011, Yang et al. 2020). The antisense transcript GATA6-AS1 lncRNA from an upstream region of the GATA6 coding sequence enhances the interaction of SMAD2,3 with the GATA6 promoter (Yang et al. 2020). GATA6-AS1 is required for differentiation of definitive endoderm from embryonic stem cells (Yang et al. 2020)
Literature References
PubMed ID Title Journal Year
19564924 Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways

Vallier, L, Touboul, T, Chng, Z, Brimpari, M, Hannan, N, Millan, E, Smithers, LE, Trotter, M, Rugg-Gunn, P, Weber, A, Pedersen, RA

PLoS One 2009
17204604 Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed

McLean, AB, D'Amour, KA, Jones, KL, Krishnamoorthy, M, Kulik, MJ, Reynolds, DM, Sheppard, AM, Liu, H, Xu, Y, Baetge, EE, Dalton, S

Stem Cells 2007
21630377 Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors

Brown, S, Teo, A, Pauklin, S, Hannan, N, Cho, CH, Lim, B, Vardy, L, Dunn, NR, Trotter, M, Pedersen, R, Vallier, L

Stem Cells 2011
32795420 GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation

Yang, J, Lu, P, Li, M, Yan, C, Zhang, T, Jiang, W

Stem Cell Reports 2020
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-2S-SMAD2,3:GATA6-AS1 lncRNA:GATA6 gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2023-01-11)
Reviewed
Salehin, N  (2023-02-28)
Tam, PPL  (2023-02-28)
Created
May, B  (2023-01-13)
Cite Us!