Expression of GATA6 in definitive endoderm

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Reaction [uncertain]
Homo sapiens
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In mouse embryos, Gata6 is expressed in the primitive streak and continues expression in the definitive endoderm (Morrisey et al. 1996, Freyer et al. 2015, Wen et al. 2017). In human embryonic stem cell models, GATA6 is required for formation of definitive endoderm and pancreas development (Tiyaboonchai et al.2017, Chia et al. 2019). In the definitive endoderm, NODAL signaling activates transcription of GATA6 via the phosphorylation of SMAD2 and SMAD3, which bind the GATA6 promoter (inferred from human pluripotent stem cells in McLean et al. 2007, Vallier et al. 2009, Brown et al. 2011, Yang et al. 2020). The antisense transcript GATA6-AS1 lncRNA from an upstream region of the GATA6 coding sequence enhances the interaction of SMAD2,3 with the GATA6 promoter (Yang et al. 2020). GATA6-AS1 is required for differentiation of definitive endoderm from embryonic stem cells (Yang et al. 2020)
Literature References
PubMed ID Title Journal Year
19564924 Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways

Weber, A, Pedersen, RA, Chng, Z, Vallier, L, Hannan, N, Rugg-Gunn, P, Smithers, LE, Touboul, T, Millan, E, Trotter, M, Brimpari, M

PLoS One 2009
17204604 Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed

Xu, Y, McLean, AB, Dalton, S, Liu, H, Kulik, MJ, D'Amour, KA, Sheppard, AM, Krishnamoorthy, M, Baetge, EE, Reynolds, DM, Jones, KL

Stem Cells 2007
21630377 Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors

Dunn, NR, Lim, B, Cho, CH, Vallier, L, Pedersen, R, Hannan, N, Teo, A, Vardy, L, Brown, S, Trotter, M, Pauklin, S

Stem Cells 2011
32795420 GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation

Yan, C, Yang, J, Zhang, T, Li, M, Jiang, W, Lu, P

Stem Cell Reports 2020
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