SMAD2,3, FOXA2, TBXT, and GATA6 bind the GATA4 gene

Stable Identifier
R-HSA-9823836
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SMAD2,3, FOXA2, TBXT, and GATA6 bind the GATA4 gene
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NODAL signaling in the anterior primitive streak leads to the phosphorylation of SMAD2 and SMAD3, which co-translocate with SMAD4 to the nucleus and bind the promoter of the GATA4 gene (inferred from human pluripotent stem cells in Brown et al. 2011). GATA6 and EOMES (Chia et al. 2019) and TBXT (Faial et al. 2015), initially expressed in the primitive streak, also bind and activate transcription of GATA4. FOXA2 binds an intronic enhancer in the GATA4 gene in definitive endoderm progenitors and activates transcription in the gut tube populated by the endoderm (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
30629940 GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation

Dunn, NR, Garcia-Bernardo, J, Chia, CY, Hattersley, AT, Madrigal, P, Vallier, L, Chhatriwala, M, Denil, SLIJ, El-Khairi, R, Shepherd, MH, Martinez, I

Stem Cell Reports 2019
21630377 Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors

Dunn, NR, Lim, B, Cho, CH, Vallier, L, Pedersen, R, Hannan, N, Teo, A, Vardy, L, Brown, S, Trotter, M, Pauklin, S

Stem Cells 2011
26015544 Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells

Smith, JC, Diamanti, E, Pedersen, RA, Trotter, MW, Mascetti, VL, Faial, T, Gentsch, GE, Ortmann, D, Bernardo, AS, Mendjan, S

Development 2015
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Inferred From
Foxa2 binds the Gata4 gene (Mus musculus)
Authored
May, B  (2023-01-11)
Reviewed
Tam, PPL  (2023-02-28)
Salehin, N  (2023-02-28)
Created
May, B  (2023-01-11)
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