KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3)

Stable Identifier
R-HSA-9822985
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
KDM6A (UTX) demethylates histone H3 trimethyllysine-27 (H3K27me3, lysine-28 of the preprotein) to yield histone H3 monomethyllysine-27 (H3K27me1) in embryonic cells (Agger et al. 2007, Hong et al. 2007, Lan et al. 2007) and is inferred to catalyze the same reaction in zygotes. KDM6A participates in demethylating genome-wide H3K27me3 in cleavage stage embryos (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
17851529 A histone H3 lysine 27 demethylase regulates animal posterior development

Rinn, JL, Wang, JK, Lan, F, Shi, Y, Issaeva, I, Chang, HY, Whetstine, JR, Alpatov, R, Iwase, S, Chen, S, Bayliss, PE, Roberts, TM, Canaani, E

Nature 2007
18003914 Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases

Ge, K, Hong, S, Yu, H, Yu, LR, Veenstra, TD, Cho, YW

Proc Natl Acad Sci U S A 2007
17713478 UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

Helin, K, Canaani, E, Salcini, AE, Issaeva, I, Christensen, J, Rose, S, Agger, K, Rappsilber, J, Pasini, D, Cloos, PA

Nature 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

histone H3K27me2/H3K27me3 demethylase activity of KDM6A:Fe2+ [nucleoplasm]

Physical Entity
KDM6A:Fe2+ [nucleoplasm] (Homo sapiens)
Activity
histone H3K27me2/H3K27me3 demethylase activity (GO:0071558)
Inferred From
Kdm6a (Utx) demethylates trimethylated histone H3 lysine-27 (H3K27me3) (Mus musculus)
Authored
May, B  (2022-12-28)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2023-01-03)
Cite Us!