METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein)

Stable Identifier
R-HSA-9822583
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein)
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METTL23 catalyzes the asymmetric dimethylation of arginine-17 of histone H3.3 (arginine-18 of the preprotein) (inferred from mouse homologs). Dimethylation of histone H3.3 is required for assembly of H3.3 into chromatin in the male pronucleus of the zygote (inferred from mouse homologs).
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Output
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as an event of
Catalyst Activity

histone methyltransferase activity of METTL23 [nucleoplasm]

Physical Entity
METTL23 [nucleoplasm] (Homo sapiens)
Activity
histone methyltransferase activity (GO:0042054)
Inferred From
Mettl23 dimethylates histone H3.3 arginine-18 (arginine-17 in the mature protein) (Mus musculus)
Authored
May, B  (2022-12-26)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-12-26)
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