CCR4-NOT(CNOT6L) deadenylates mRNA in CCR4-NOT(CNOT6L):ZFP36L2:mRNA

Stable Identifier
R-HSA-9822335
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CCR4-NOT(CNOT6L) deadenylates mRNA in CCR4-NOT(CNOT6L):ZFP36L2:mRNA
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ZFP36L2 bound to AU-rich elements of specific mRNAs recruits the CCR4-NOT complex via an interaction between ZFP36L2 and CNOT6L of the CCR4-NOT complex (inferred from mouse homologs). CNOT6L then deadenylates the mRNA, targeting the mRNA for degradation (inferred from mouse homologs).
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Output
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Catalyst Activity

poly(A)-specific ribonuclease activity of CCR4-NOT(CNOT6L):ZFP36L2:mRNA [cytosol]

Physical Entity
CCR4-NOT(CNOT6L):ZFP36L2:mRNA [cytosol] (Homo sapiens)
Activity
poly(A)-specific ribonuclease activity (GO:0004535)
Inferred From
CCR4-NOT(Cnot6l) deadenylates mRNA in CCR4-NOT(Cnot6l):Zfp36l2:mRNA (Mus musculus)
Authored
May, B  (2022-12-22)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-12-23)
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