NPM2 dissociates p-S9-PRM1 from HIRA:NPM2:p-S9-PRM1:dsDNA

Stable Identifier
R-HSA-9822115
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NPM2 dissociates p-S9-PRM1 from HIRA:NPM2:p-S9-PRM1:dsDNA
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NPM2 dissociates phosphorylated PRM1 from DNA (inferred from mouse homologs). Deletion of Npm2 from mouse oocytes does not prevent protamine removal (Burns et al. 2003), indicating that other factors such as Npm1 and Npm3 may act redundantly with Npm2 (Okuwaki et al. 2012).
Literature References
PubMed ID Title Journal Year
22362753 Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling

Okuwaki, M, Sumi, A, Hisaoka, M, Saotome-Nakamura, A, Akashi, S, Nishimura, Y, Nagata, K

Nucleic Acids Res 2012
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Catalyst Activity

ATP-dependent protein-DNA complex displacement activity of HIRA:NPM2:p-S9-PRM1:dsDNA [nucleoplasm]

Physical Entity
HIRA:NPM2:p-S9-PRM1:dsDNA [nucleoplasm] (Homo sapiens)
Activity
ATP-dependent protein-DNA complex displacement activity (GO:0061995)
Inferred From
Npm2 dissociates p-S9,S43-Prm1 from Hira:Npm2:p-S9,S43-Prm1:dsDNA (Mus musculus)
Authored
May, B  (2022-12-18)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-12-19)
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