Reactome | HCFC1 binds SET1A complex

HCFC1 binds SET1A complex

Stable Identifier

R-HSA-9821486

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The SET1A complex binds to HCFC1 (also known as Host cell factor 1 or HCF-1) (Wysocka et al. 2003; Tyagi et al. 2007; Lee and Skalnik 2008). The interaction involves the N-terminal half of HCFC1 and the evolutionarily conserved HCF-1 binding motif EHNY in the C-terminal half of SETD1A (Wysocka et al. 2003), which is not present in SETD1B (Lee et al. 2007). HCFC1 may enable formation of super-complexes that involve the SET1A complex and the SIN3A histone deacetylase complex (HDAC) (Wysocka et al. 2003). HCFC1 may enable association of the SET1A complex with E2F proteins, leading to the recruitment of SET1A complexes to promoters of E2F-target genes (Tyagi et al. 2007). Antibodies against WDR82, a protein that binds to the core SET1A complex, can pull down HCFC1, so HCFC1 is shown to bind to the SET1A complex or the SET1A complex associated with CXXC1 and WDR82 (Wu et al. 2008; van Nuland et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23508102	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes Pallaki, P, Smits, AH, van Nuland, R, Jansen, PW, Timmers, HT, Vermeulen, M	Mol Cell Biol	2013
12670868	Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 Laherty, CD, Myers, MP, Eisenman, RN, Herr, W, Wysocka, J	Genes Dev.	2003
18838538	Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS Florens, L, Martin-Brown, S, Lee, JS, Washburn, M, Wu, M, Shilatifard, A, Wang, PF	Mol Cell Biol	2008
17612494	E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases Chabes, AL, Tyagi, S, Herr, W, Wysocka, J	Mol Cell	2007
17998332	Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes Skalnik, DG, Lee, JH	Mol Cell Biol	2008