Reactome | PAXIP1 binds PAGR1

PAXIP1 binds PAGR1

Stable Identifier

R-HSA-9821395

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- Epigenetic regulation of gene expression (Homo sapiens)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
    - Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
      - PAXIP1 binds PAGR1 (Homo sapiens)
    - Formation of WDR5-containing histone-modifying complexes (Homo sapiens)
      - PAXIP1 binds PAGR1 (Homo sapiens)

General

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PAXIP1 (also known as Pax2 transactivation domain interaction protein or PTIP) forms a complex with PAGR1 (also known as PTIP-associated protein or PA1). Formation of the PAXIP1:PAGR1 complex has been shown between endogenous proteins in human embryonic kidney cell line HEK293T (Gong et al. 2009) and between endogenous proteins in mouse embryonic fibroblasts (MEFs) and mouse primary B cells (Starnes et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
19124460	Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage Ge, K, Kim, JE, Chen, J, Gong, Z, Cho, YW	J Biol Chem	2009