Reactome | AKAP8L [nucleoplasm]

AKAP8L [nucleoplasm]

Stable Identifier

R-HSA-9821364

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

A-kinase anchor protein 8-like, AKP8L_HUMAN, AKAP95

Locations in the PathwayBrowser for interactor UniProt:Q8NEC5 CATSPER1

Expand all

External Reference Information

External Reference

UniProt:Q9ULX6 AKAP8L

Gene Names

AKAP8L, NAKAP, NAKAP95, HRIHFB2018

Chain

chain:1-646

Reference Genes

BioGPS Gene:26993 AKAP8L

COSMIC (genes):AKAP8L AKAP8L

CTD Gene:26993 AKAP8L

dbSNP Gene:26993 AKAP8L

ENSEMBL:ENSG00000011243 AKAP8L

ENSEMBL_homo_sapiens_GENE:ENSG00000011243.19 AKAP8L

HGNC:29857 AKAP8L

KEGG Gene (Homo sapiens):26993 AKAP8L

Monarch:26993 AKAP8L

NCBI Gene:26993 AKAP8L

OMIM:609475 AKAP8L

UCSC:Q9ULX6 AKAP8L

Reference Transcript

Other Identifiers

11730171_a_at

11750884_a_at

16869860

218064_3p_s_at

218064_PM_s_at

218064_s_at

26993

3853346

3853347

3853348

3853349

3853351

3853366

3853367

3853368

3853383

3853389

3853391

3853392

3853394

3853397

3853398

3853399

3853401

3853403

3853405

43345_at

55687_at

8035023

A_23_P153767

GE55840

GO:0000278

GO:0000785

GO:0003677

GO:0003723

GO:0005515

GO:0005521

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006351

GO:0006355

GO:0006397

GO:0006913

GO:0007059

GO:0007076

GO:0008380

GO:0010793

GO:0016071

GO:0016363

GO:0016605

GO:0016607

GO:0017151

GO:0034237

GO:0042826

GO:0043226

GO:0043229

GO:0044839

GO:0045944

GO:0046872

GO:0051081

GO:0061024

GO:0140014

GO:1990904

HMNXSV003008773

HMNXSV003027342

Hs.96200.1.S1_3p_a_at

Hs.96200.1.S1_3p_x_at

ILMN_1768962

PH_hs_0031425

TC19001254.hg

g7657354_3p_a_at

Participates

as a component of

as an input of

Inferred To

akap8l [nucleoplasm] (Xenopus tropicalis)

AKAP8L [nucleoplasm] (Bos taurus)

AKAP8L [nucleoplasm] (Gallus gallus)

AKAP8L [nucleoplasm] (Sus scrofa)

Akap8l [nucleoplasm] (Mus musculus)

Akap8l [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_055186.3, NP_001278407.1

OpenTargets

ENSG00000011243

GeneCards

Q9ULX6

HPA

ENSG00000011243-AKAP8L

Ensembl

ENST00000595465, ENSG00000011243, ENSP00000380557, ENST00000397410, ENSP00000470952

PRO

Q9ULX6

Pharos - Targets

Q9ULX6

Interactors (68)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.666	4
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.612	5
UniProt:Q7Z6R9 TFAP2D	1	TFAP2D [nucleoplasm] (R-HSA-5626817)	0.556	3
UniProt:Q5T749 KPRP	1	KPRP [cytosol] (R-HSA-9839614)	0.556	3
UniProt:Q9H0L4 CSTF2T	1	CSTF2T [nucleoplasm] (R-HSA-8938786)	0.556	3
UniProt:Q15915 ZIC1	1	ZIC1 [nucleoplasm] (R-HSA-9731648)	0.556	3
UniProt:Q9BTL3 RAMAC			0.556	3
UniProt:Q8N895 ZN366			0.556	3
UniProt:Q8NEC5 CATSPER1	1	CATSPER1 [plasma membrane] (R-HSA-2534335)	0.556	3
UniProt:Q9UBV8 PEF1			0.556	3
UniProt:Q7Z5V6-2 SAXO4			0.556	3
UniProt:Q9NQL9 DMRT3			0.556	3
UniProt:Q96M29 TEKT5			0.556	3
UniProt:Q96RU7 TRIB3	3	TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [cytosol] (R-HSA-162411) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.556	3
UniProt:Q9H0I2 ENKD1			0.556	3
UniProt:Q14D33 RTP5			0.556	3
UniProt:Q02930-3 CREB5			0.556	3
UniProt:Q64LD2-2 WDR25			0.556	3
UniProt:Q9NP98 MYOZ1			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q9HBE1-4 PATZ1			0.556	3
UniProt:Q494U1-3 PLEKHN1			0.556	3
UniProt:A8K8V0 ZNF785	1	ZNF785 [nucleoplasm] (R-HSA-3323098)	0.556	3
UniProt:Q9Y2V2 CHSP1			0.556	3
UniProt:Q8N5M1 ATPF2			0.556	3
UniProt:Q13227 GPS2	1	GPS2 [nucleoplasm] (R-HSA-351642)	0.556	3
UniProt:Q8TEC5 SH3R2			0.556	3
UniProt:P33240 CSTF2	1	CSTF2 [nucleoplasm] (R-HSA-72003)	0.556	3
UniProt:Q8WU58 F222B			0.556	3
UniProt:Q9Y5E9 PCDBE			0.556	3
UniProt:Q86VE0 MYPOP			0.556	3
UniProt:Q8NE01 CNNM3			0.556	3
UniProt:Q9BVN2 RUSC1			0.556	3
UniProt:Q96A09 TET5B			0.556	3
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.556	3
UniProt:Q8N4L8 CCD24			0.556	3
UniProt:Q9UPU9-3 SAMD4A			0.556	3
UniProt:P62328 TMSB4X	2	TMSB4X [extracellular region] (R-HSA-349753) TMSB4X [platelet alpha granule lumen] (R-HSA-349758)	0.556	3
UniProt:Q14129 DGCR6			0.556	3
UniProt:Q96HB5 CC120			0.556	3
UniProt:Q8IYX7 SAXO1			0.556	3
UniProt:Q8WW24 TEKT4			0.556	3
UniProt:P15202	5	CAT [cytosol] (R-SCE-9033141) CAT [secretory granule lumen] (R-SCE-6801311) CAT [extracellular region] (R-SCE-6806458) CAT [ficolin-1-rich granule lumen] (R-SCE-6801279) CAT [peroxisomal matrix] (R-SCE-51417)	0.556	3
UniProt:O95872 GPAN1			0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:P29597 TYK2	5	p-TYK2 [cytosol] (R-HSA-8950424) p-Y-TYK2 [cytosol] (R-HSA-6784366) TYK2 [cytosol] (R-HSA-877348) p-Y1054,Y1055-TYK2 [cytosol] (R-HSA-909682) p-Y1054-TYK2 [cytosol] (R-HSA-1112598)	0.556	3
UniProt:Q12950 FOXD4			0.556	3
UniProt:Q16512 PKN1	3	p-T774-PKN1 [nucleoplasm] (R-HSA-5625721) p-T774-PKN1 [cytosol] (R-HSA-5623651) PKN1 [cytosol] (R-HSA-5623613)	0.556	3
UniProt:Q7L5A3 ATOSB			0.556	3
UniProt:Q9NYB9-2 ABI2			0.556	3
UniProt:Q14657 LAGE3	1	LAGE3 [nucleoplasm] (R-HSA-6784525)	0.556	3
UniProt:Q01085-2 TIAL1			0.556	3
UniProt:P78337 PITX1			0.556	3
UniProt:Q9Y5R4 HEMK1			0.556	3
UniProt:Q9ULV5-2 HSF4			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q3SY00 T10IP			0.556	3
UniProt:Q8TAP9 MPLKI			0.556	3
UniProt:Q8AZK7 EBNA5			0.527	2
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.527	2
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.527	9
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.527	2
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.527	2
UniProt:Q68DV7 RNF43	10	RNF43 E174* [plasma membrane] (R-HSA-5340574) RNF43 R330fs89 [plasma membrane] (R-HSA-5340581) RNF43 A169T [plasma membrane] (R-HSA-9666639) RNF43 R117Afs41 [plasma membrane] (R-HSA-9666664) RNF43 R132* [plasma membrane] (R-HSA-9666650) RNF43 P154L [plasma membrane] (R-HSA-9666646) RNF43 F69C [plasma membrane] (R-HSA-5340578) RNF43 [plasma membrane] (R-HSA-5323531) ub-RNF43 [plasma membrane] (R-HSA-5323547) RNF43 G659Vfs*41 [plasma membrane] (R-HSA-9666643)	0.508	2
UniProt:Q9R1C7	1	Prpf40a [nucleoplasm] (R-MMU-8867890)	0.508	3
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.499	2
UniProt:P12504 VIF			0.462	2

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