Reactome | HCFC1, HCFC2 bind the MLL1:MEN1 complex

HCFC1, HCFC2 bind the MLL1:MEN1 complex

Stable Identifier

R-HSA-9821235

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Both HCFC1 (also known as Host cell factor 1 or HCF1) and HCFC2 (also known as Host cell factor 2 or HCF2) can associate with the complex of MLL1 and MEN1 (Yokoyama et al. 2004; van Nuland et al. 2013) and pull down the components of the WRAD subcomplex (Yokoyama et al. 2004). The interaction occurs by binding of HCFC1 or HCFC2 to the N-terminal cleavage fragment of KMT2A (also known as MLL1 or MLL). HCFC2 appears to be the preferential binding partner of KMT2A. It is uncertain whether HCFC1 or HCFC2, when bound to the MLL1:MEN1 complex, associate with the HOXA9 gene promoter (Yokoyama et al. 2004). There is no evidence currently that MEN1 is required for binding of HCFC1 or HCFC2 to KMT2A.

HCFC1-mediated recruitment of MLL1 is needed for H3K4 trimethylation and transcriptional activation of herpesvirus immediate early promoters at the onset of infection (Narayanan et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
23508102	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes Pallaki, P, Smits, AH, van Nuland, R, Jansen, PW, Timmers, HT, Vermeulen, M	Mol Cell Biol	2013
15199122	Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression Cleary, ML, Aufiero, DJ, Herr, W, Sanyal, M, Wang, Z, Yokoyama, A, Kitabayashi, I, Wysocka, J	Mol Cell Biol	2004